Y.X. Fan
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combinat.. Read More»
Genet. Mol. Res. 16(2): gmr16029414
DOI: 10.4238/gmr16029414
Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)
Previous molecular genetic studies of the goat hair life cycle have focused primarily on a limited number of genes and proteins. To identify additional genes that may play important roles in hair follicle cycle regulation, Illumina sequencing technology was used to catalog differential gene expression profiles in the hair growth cycle (anagen to catagen) of goat, comparing the primary hair foll.. Read More»
Genet. Mol. Res. 14(4): 2015.December.22.15
DOI: 10.4238/2015.December.22.15
Discovery of differentially expressed genes in cashmere goat (Capra hircus) hair follicles by RNA sequencing
The mammalian hair follicle (HF) is a unique, highly regenerative organ with a distinct developmental cycle. Cashmere goatCapra hircus) HFs can be divided into two categories based on structure and development time: primary and secondary follicles. To identify differentially expressed genes (DEGs) in the primary and secondary HFs of cashmere goats, the RNA sequencin.. Read More»
Genet. Mol. Res. 15(3): gmr.15038589
DOI: 10.4238/gmr.15038589
Effects of different dietary intake on mRNA levels of MSTN, IGF-I, and IGF-II in the keletal muscle of Dorper and Hu sheep hybrid F1 rams
MSTN, IGF-Ð?(insulin-like growth factor-Ð?) and IGF-II (insulin-like growth factor-II) regulate skeletal muscle growth. This study investigated the effects of different dietary intake levels on skeletal muscles. Sheep was randomly assigned to 3 feeding groups: 1) the maintenance diet (M), 2) 1.4 x the maintenance diet (1.4M), and 3) 2.15 x the .. Read More»
Genet. Mol. Res. 13(3): 2014.July.24.4
DOI: 10.4238/2014.July.24.4
Analysis of imprinted messenger RNA expression in deceased transgenic cloned goats
Genomic imprinting is an important epigenetic mechanism that has vital effects on fetal growth and development. We observed the differences in four tissues (heart, spleen, liver, and kidney) from dead transgenic cloned goats using hematoxylin and eosin (H&E) staining. Eight imprinted genes in the tissues of dead transgenic cloned and normal goats were analyzed using reverse transcription po.. Read More»
Genet. Mol. Res. 15(1): gmr.15017455
DOI: 10.4238/gmr.15017455
A possible way that Ï?C31 integrase regulates the recombination direction
φC31 integrase encoded by Streptomyces phage can mediate site-specific recombination between phage and host genomes. The recombination direction is generally considered to be accurately regulated, but the regulatory mechanisms involved are still unclear. Recently, some hyperactive mutants of φC31 integrase that can bypass the regulatory steps have been isolated and extensively studied. .. Read More»
Genet. Mol. Res. 14(1): 2015.January.26.4
DOI: 10.4238/2015.January.26.4
Oct4 and Sox2 overexpression improves the proliferation and differentiation of bone mesenchymal stem cells in Xiaomeishan porcine
Mesenchymal stem cells derived from bone marrow (BMSCs) are a population of self-renewing multipotent cells that are capable of differentiating into various cellular lineages, and are widely employed in tissue engineering and cell therapy. Recently, clinical research involving BMSCs has become increasingly popular. In order to conduct appropriate research, it is fir.. Read More»
Genet. Mol. Res. 12(4): 2013.December.2.5
DOI: 10.4238/2013.December.2.5
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