Uncoupling Proteins and Cardiac Apoptosis in High Fat Diet-Fed Male Rats
Authors: K. Alsolami, Z. Alrefaie
This study aimed to assess impact of high fat diet (HFD) on cardiac apoptosis, and cardiac uncoupling proteins (UCPs) 2&3 expression. Twenty rats were fed either (45%) or (10%) fat diet for 6 months, then cardiac tissue expression of BAX, Bcl2, Fas, Fas-L (markers for apoptotic pathways) and UCP 2&3 were assessed. Results revealed enhancement of i.. Read More»
- Genet. Mol. Res. 19(1):
Asp299Gly polymorphism in TLR4 gene in patients with colorectal cancer
Authors: S. M. Shoeib, W. S. Mohamed, H. M. Nagy
Background: Toll-like receptors play important roles in innate and adaptive immunity and polymorphisms within TLR-4 as Asp299Gly are reported to be associated with certain digestive cancers e.g. colorectal carcinoma. Aim: Investigate the association between Asp299Gly polymorphism and the risk of colorectal cancer .. Read More»
- Genet. Mol. Res. 18(1):
Electroporation induced membrane permeability changes at the ionic level
Authors: Sadasivam Pachamuthu, Zubin A Zaheer, Bhuvaneshwari Sampath, Dharani Muralidharan, Rajaprabu Ramachandran and Kavitha Sankaranarayanan
Background/Aim: Electrochemotherapy is an innovative method for the localized treatment of cutaneous and subcutaneous metastatic cancers. The aim of the study is to assess the changes at the plasma membrane and its recovery time by monitoring the regulated passage of ions through specific ion channels as measured by electrophysiology. Materials an.. Read More»
- Genet. Mol. Res. 18(3):
Behavior of soybean genotypes in three locations in the Triângulo Mineiro
Authors: R.M.G. Diniz, O.T. Hamawaki, A.P.O. Nogueira, C.O. Silva, R.L. Hamawaki, C.D.L. Hamawaki, F.C. Juliatti, S.L.A. Filho
Soy is an important legume for global economy. The objectives of this study were evaluated soybean genotypes in different growing environments as for their agronomic characters and resistance to leaf spots, and determine the adaptability and phenotypic stability of materials in relation to the place of cultivation. Experiments were conducted in the cities.. Read More»
- Genet. Mol. Res. 18(3):
Differential expression of genes associated with low-level vancomycin resistance in Staphylococcus aureus
Authors: Auttawit Sirichoat, Viraphong Lulitanond, Sujintana Wongthong, Aroonwadee Chanawong, Ratree Tavichakorntrakool and Aroonlug Lulitanond
Heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) have been associated with treatment failure, and hVISA cannot be detected by routine disc diffusion test. Currently, there is no specific genetic marker for detection of these strains. The aim of the current study was to inves.. Read More»
- Genet. Mol. Res. 18(2):
Development and characterization of microsatellite molecular markers for the eye mask frog Batrachyla taeniata (Girard, 1855)
Authors: Ingrid Cisternas-Medina, Juan Carlos Ortiz and Sandra Ferrada-Fuentes
Batrachyla taeniata (Batrachylidae) is a small frog from Chile and Argentina with a distributional range that spans more than 1500 km. However, their populations are threatened due to the change in land use, deforestation, and human settlements. Through massive sequencing runs in ION Torrent PGM, was built DNA fragment library, from which we fina.. Read More»
- Genet. Mol. Res. 18(2):
Expression of HCN and sodium channels in murine model of Type I diabetes
Authors: Anantha Maharasi Rama Krishnan and Kavitha Sankaranarayanan
Pancreatic apoptosis is an important event in the pathogenesis of Type 1 Diabetes. It is characterized by secretion and binding of inflammatory cytokines to the pancreatic islets, that activate downstream signaling mechanism. These signaling mechanisms finally increase intracellular calcium level and that lead to the activation of apoptotic pathways. Ion .. Read More»
- Genet. Mol. Res. 18(2):
Dynamism of the breeding program for irrigated rice in Southeast Brazil
Authors: A.C. Silva J�ºnior, V.Q. Carneiro, I.G. Santos, W.G Costa, R.D.S. Rosado, C.D. Cruz and P.C. Soares
The estimation of the genotypic replacement rate is aimed at evaluating the performance of breeding programs. Thus, the objective of this study was to evaluate the dynamics of the genetic improvement program of flooded rice, developed in Minas Gerais, during the period from 1993 to 2016. We evaluated 210 lines in three environments between 1993 and 2016, .. Read More»
- Genet. Mol. Res. 19(5):
Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet
Authors: Khadeejah Mesaid Al-Solami, Zienab Alrefaie, Hossam Awad
Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial path.. Read More»
- Genet. Mol. Res. 19(5):
Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients
Authors: S. Babi Heera, Umme Najiya Mahwish, Fazul Rahman, Sayeeduddin S, Sree Bhushan Raju , Parveen Jahan
Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE.. Read More»
- Genet. Mol. Res. 19(5):