Association between TAP1 gene polymorphisms and alopecia areata in a Korean population
Authors: H.K. Kim, H. Lee, B.L. Lew, W.Y. Sim, Y.O. Kim, S.W. Lee, S. Lee, I.K. Cho, J.T. Kwon and H.J. Kim
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alope.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.31
- DOI:
- 10.4238/2015.December.28.31
Expression patterns of melatonin receptors in chicken ovarian follicles affected by monochromatic light
Authors: D.Y. Li, N. Wu, J.B. Tu, Y.D. Hu, M.Y. Yang, H.D. Yin, B.L. Chen, H.L. Xu, Y.F. Yao and Q. Zhu
Artificial illumination is an important exogenous factor in the control of many physiological and behavioral processes as well as an important environmental factor in the management of laying hens. Melatonin receptors are members of the G protein-coupled receptor family. The hormone melatonin is secreted primarily by the pineal gland, with highest levels .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.14
- DOI:
- 10.4238/2015.August.21.14
Molecular identification of Achyranthis Bidentatae Radix by using DNA barcoding
Authors: D.-Y. Hou, G.-P. Wang, L.-H. Zhi, H.-W. Xu, H.-L. Liang, M.-M. Yang and G.-A. Shi
Achyranthis Bidentatae Radix has a long history in China as a commonly used herb that can be used to treat various diseases, including those related to the liver, muscles, bones, and kidneys. Recently, an increase in the number of adulterants has been reported, which affects the clinical safety of Achyranthis Bidentatae Radix... Read More»
- Genet. Mol. Res. 15(2):
Association between PAI-1 polymorphisms and plasma PAI-1 level with sepsis in severely burned patients
Authors: Y.F. Chi, J.K. Chai, Y.M. Yu H.M. Luo, Q.X. Zhang and R. Feng
We investigated the association between plasminogen activator inhibitor-1 (PAI-1) polymorphisms and plasma PAI-1 level with sepsis in severely burned patients. A total of 182 patients with burn areas lager than 30% of the body surface area were enrolled in this study. Peripheral blood samples were obtained from 103 patients with sepsis (sepsis group) and .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.15
- DOI:
- 10.4238/2015.August.21.15
Polymorphisms in GJA1 and their association with growth traits in chicken
Authors: M. Shahjahan, R.R. Liu, G.P. Zhao, J.J. Zhang, M.Q. Zheng, Q.H. Li and J. Wen
This study aimed to screen single nucleotide polymorphisms (SNPs) in the chicken gap junction protein alpha 1 (GJA1) gene, and to investigate their association with five growth traits measured in 269 chickens encompassing Chinese indigenous Beijing-You (BJY) and commercial Cobb broiler (CB) populations. Four variants were detected in the chicken GJA1 gene.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.33
- DOI:
- 10.4238/2015.December.28.33
Rapid and sensitive LC-MS/MS method for the determination of auraptene in rat plasma and its application in a pharmacokinetic and bioavailability study in rats
Authors: X.D. Ye, H. Ouyang, L.Y. Zhong, T.E. Li, X.Y. Rao, Y.L. Feng and W.L. Yang
A simple, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of auraptene, a constituent isolated from Fructus aurantii with potential to combat Alzheimer’s disease, in rat plasma. Rat plasma samples were pretreated by protein precipitation with .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028786
- DOI:
- 10.4238/gmr.15028786
Role of autoantibodies to various Ro60 epitopes in the decrease of lymphocytes seen in systemic lupus erythematosus and primary Sj�¶grenâ��s syndrome
Authors: Z.W. Shuai, Y. Huang, L. Zhang, J. Cai and M. Li
We investigated the roles of autoantibodies to different Ro60 epitopes in lymphopenia in systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). We recruited 16 patients with SLE, 14 with pSS, and 10 healthy controls; all were female. Patients had active disease, had not received glucocorticoid or immunosuppressants for at leas.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.17
- DOI:
- 10.4238/2015.August.21.17
Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis
Authors: B. Zhu, L. Yin and J.Y. Zhang
The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patien.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.34
- DOI:
- 10.4238/2015.December.28.34
Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients
Authors: D.-L. Jiang, J. Yang, S.-Y. Jiang, F.-L. Yuan, Y.-L. Gu, J.-P. Li and Z.-J. Pei
We investigated the role of modified Da Chengqi granules in improving immune function in early severe acute pancreatitis patients. Early severe acute pancreatitis patients who agreed to receive combined treatment of traditional Chinese and Western medicine were randomly assigned to the experimental or control group. All subjec.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028787
- DOI:
- 10.4238/gmr.15028787
Comparative proteomic analysis reveals mite (Varroa destructor) resistance-related proteins in Eastern honeybees (Apis cerana)
Authors: T. Ji, F. Shen, Z. Liu, L. Yin, J. Shen, Q. Liang and Y.X. Luo
The mite (Varroa destructor) has become the greatest threat to apiculture worldwide. As the original host of the mite, Apis cerana can effectively resist the mite. An increased understanding of the resistance mechanisms of Eastern honeybees against V. destructor may help researchers to protect other species against these parasites. In this study, the prot.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.18
- DOI:
- 10.4238/2015.August.21.18