Allele
Usefulness of direct sequencing of pooled DNA for SNP identification and allele-frequency determination compatible with a common disease/common variant hypothesis
Authors: M.K. Kim, T.S. Nam, K.H. Choi, S.Y. Jang, Y.O. Kim and M.C. Lee
We examined the efficiency of direct sequencing of pooled DNA for developing common single nucleotide polymorphisms (SNPs) and its accuracy for estimating allele frequencies. A pool of 200 control DNAs was established and was used for developing SNPs and estimating minor allele frequencies (MAF). The sensitivity of the pooled .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr761
- DOI:
- 10.4238/vol9-2gmr761
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population J.
Authors: J.M. Liu, S.H. Cheng, C. Xia, T. Deng, Y.C. Zhu, X. Wei, Z.L. Huang, B.H. Liao, D.Y. Luo, Y.G. Zhang, T. Jin, K.J. Wang, J. Huang, H. Li
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated be.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019469
- DOI:
- 10.4238/gmr16019469
A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico
Authors: L. GarcÃ?Âa-Ortiz, G. Vargas-AlarcÃ?³n, J.M. Fragoso, J. Granados, L. Maldonado Noriega, A. Navas PÃ?©rez , E. Huerta Reyes, J.C. Zenteno-Ruiz and E. MartÃ?Ânez-Cordero
The human orosomucoid 1 gene (ORM1) codes an alpha-1-acid glycoprotein that has been classified as an acute-phase reactive protein, and a major drug-binding serum component, as well as an immunomodulatory protein with genetic polymorphisms. Evaluation of ORM variation through isoelectric focusing and immunobloting has revealed a world-wide distribution of.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr348
- DOI:
- 10.4238/vol7-1gmr348
Allele frequencies for 12 autosomal short tandem repeat loci in two bolivian populations
Authors: L. Cifuentes, H. Jorquera, M. Acu�±a, J. Ord�³�±ez and A.L. Sierra
Two hundred and sixty unrelated subjects who asked for paternity testing at two Bolivian Laboratories in La Paz and Santa Cruz were studied. The loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, TH01, TPOX, and CSF1PO were typed from blood samples, amplifying DNA by polymerase chain reactions and electr.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr368
- DOI:
- 10.4238/vol7-1gmr368
Genetic analysis of 30 InDel markers for forensic use in five different Chinese populations
Authors: C.T. Li, S.H. Zhang and S.M. Zhao
Allele frequencies of 30 insertion/deletion polymorphism (InDel) markers previously selected and validated for forensic purposes were assessed in 419 unrelated individuals originating from five different populations of P.R. China, including Chinese Han, Chinese Hui, Uighur, Mongolians, and Tibetans. Hardy-Weinberg equilibrium .. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1082
- DOI:
- 10.4238/vol10-2gmr1082
Non-parental banding patterns in recombinant inbred line population of maize with SSR markers
Authors: R.V. Ramekar, K.J. Sa, S.Y. Woo and J.K. Lee
We observed 3 types of non-parental banding patterns using simple-sequence repeat primers in a recombinant inbred line maize population developed from 2 inbred lines, Mo17 and KW7. We observed alleles that were not present in either of the parents, known as non-parental alleles. Although non-parental alleles are a consequence of genetic variation, they ar.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.9
- DOI:
- 10.4238/2015.July.28.9
Polymorphism in the A2M gene associated with high-quality milk in Murrah buffaloes (Bubalus bubalis)
Authors: A.C. Freitas, G.M.F. de Camargo, R.R. Aspilcueta-Borquis, N.B. Stafuzza, G.C. Venturini, F. Tanamati, N.A. Hurtado-Lugo, C.C. Barros and H. Tonhati
The study of genes associated with host defense mechanisms, such as the A2M gene, plays a critical role in preventing diseases that reduce milk yield and its constituents. The aim of this study was to identify polymorphisms in the A2M gene in Murrah buffaloes (Bubalus bubalis), and investigate their associations with milk yiel.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027637
- DOI:
- 10.4238/gmr.15027637
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Relationship between TBX20 gene polymorphism and congenital heart disease
Authors: X.F. Yang, Y.F. Zhang, C.F. Zhao, M.M. Liu, J.P. Si, Y.F. Fang,W.W. Xing and F.L. Wang
Congenital heart disease in children is a type of birth defect. Previous studies have suggested that the transcription factor, TBX20, is involved in the occurrence and development of congenital heart disease in children; however, the specific regulatory mechanisms are yet to be evaluated. Hence, this study aimed to evaluate th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027374
- DOI:
- 10.4238/gmr.15027374
Expressed sequence tag-simple sequence repeat-based molecular variance in two Salicornia (Amaranthaceae) populations
Authors: Z.L. Xu, Z. Ali, J.X. Yi, X.L. He, D.Y. Zhang, G.H. Yu, A.A. Khan, I.A. Khan and H.X. Ma
Salicornia spp is one of the most salt-tolerant vascular plants and is native to salt marshes and estuaries. We developed expressed sequence tag derived-simple sequence repeat (EST-SSR) markers for estimating genetic diversity and marker-assisted Salicornia breeding. Six polymorphic EST-SSRs of 40 detected 27 alleles, ranging .. Read More»
- Genet. Mol. Res. 10(2):