Apoptosis
Equine chorionic gonadotropin influence on sheep oocyte in vitro maturation, apoptosis, and follicle-stimulating hormone receptor and luteinizing hormone receptor expression
Authors: S.C. Wei, Z.D. Gong, H.W. Zhao, H.Q. Liang, L.J. Lai and Y.Y. Deng
We assessed the effects of equine chorionic gonadotropin (eCG) on oocyte in vitro maturation (IVM), apoptosis, and follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), and gonadotropin-releasing hormone receptor (GnRHR) expression and mRNA levels. Cumulus-oocyte complexes (COCs) were recovered from.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049162
- DOI:
- 10.4238/gmr15049162
Cytotoxicity and DNA damage in mouse macrophages exposed to silica nanoparticles
Authors: H. Yang1, Q.Y. Wu1,2, C.S. Lao1, M.Y. Li1, Y. Gao1, Y. Zheng1 and B. Shi3
Silica (SiO2) nanoparticles are being progressively applied in various applications, including cosmetics, food technology, and medical diagnostics. Although crystalline SiO2 is a known carcinogen, the carcinogenicity of SiO2 nanoparticles remains unclear. Here, we assessed the cytotoxic effects and DNA injury induced by exposu.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039005
- DOI:
- 10.4238/gmr.15039005
Reduction of galectin-3 expression reduces pituitary tumor cell progression
Authors: C.X. Huang, J.N. Zhao, W.H. Zou, J.J. Li, P.C. Wang, C.H. Liu and Y.B. Wang
We investigated the role of galectin 3 in the development and progression of pituitary tumors. We used RNA interference to depress Gal-3 gene expression; MTT and flow cytometry were applied to detect changes in cell proliferation and apoptosis levels in pituitary tumor cells. Expression of apoptosis-associated genes, Bcl-2 and.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.11
- DOI:
- 10.4238/2014.August.29.11
Rescue from dominant follicle atresia by follicle-stimulating hormone in mice
Authors: X.L. Zhou, Y. Teng, R. Cao, H. Fu, K. Xiong, W.X. Sun, C.C. Zhu, X.J. Huang, P. Xiao and H.L. Liu
We investigated the effects of follicle-stimulating hormone (FSH) on atresia of the dominant follicle and changes in relevant apoptosis genes in granulosa cells of dominant follicles regulated by FSH in vivo. Four-week-old mice were administered FSH by intraperitoneal injection to induce follicular maturation. Granulosa cells of dominant follicles were co.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.10
- DOI:
- 10.4238/2013.August.12.10
In situ analysis of apoptosis in Aspergillus nidulans with ethidium bromide and acridine orange
Authors: S.M. Leles, R. Factori and C.L.M.S.C. Rocha
Apoptosis and necrosis are among several types of cell death. We stained the nuclei of Aspergillus nidulans grown in micro-colonies with ethidium bromide and acridine orange to detect in situ apoptosis. Suspensions of conidia from 5-day-old colonies of the A. nidulans strains biA1methG1, G422, CLC100, and CLB3 were each put into two tubes. The suspension .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.5
- DOI:
- 10.4238/2013.August.12.5
Bovine yolk sac: from morphology to metabolomic and proteomic profiles
Authors: A.C. Galdos-Riveros, P.O. Favaron, S.E.A.L. Will, M.A. Miglino and D.A. Maria
In several species, placentation involves the presence of two different membranes responsible for maternal-fetal exchanges: the yolk sac and the chorioallantoic placenta. The yolk sac plays important roles in embryonic survival, mainly during the early stages of gestation. In bovine, it is a transitional membrane that is present until day 50-70 of pregnan.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.8
- DOI:
- 10.4238/2015.June.9.8
Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression
Authors: Z. Peng and Y. Zhang
Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027078
- DOI:
- 10.4238/gmr.15027078
Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer
Authors: L. Liu, T. Meng, Q.S. Wang, H.Z. Jin, Z.Q. Sun, B. Jin, F. Fang and H.J. Wang
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance o.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027704
- DOI:
- 10.4238/gmr.15027704
Effect of polychlorinated biphenyls on osmoregulatory response and apoptosis in GIFT tilapia, Oreochromis niloticus
Authors: Y. Zheng, L. Qiu, L. Fan, C. Song, S. Meng and J. Chen
In the present study, GIFT tilapia Oreochromis niloticus were exposed to polychlorinated biphenyls (PCBs) for 7, 14, and 21 days. Over the duration of the exposure, genotoxicity and the activity of Na+/K+-ATPase (NKA) and Ca+/Mg+-ATPase (CMA) were measured in the gill, kidney, and intestine, to evaluate changes in osmoregulatory response in O. niloticus. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038620
- DOI:
- 10.4238/gmr.15038620
Effect of cyclosporin A particles of varying diameters on gastric cancer cell apoptosis
Authors: X.L. Xing, Y. Lu and H.L. Qiu
Human health is significantly threatened by gastric cancer, which is the most common malignant tumor; although drastic, surgery is currently the only way to cure it. However, high recurrence rates and low survival rates are associated with the disease. Therefore, to improve the effectiveness of gastric cancer treatment and to .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028085
- DOI:
- 10.4238/gmr.15028085