Apoptosis
Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus
Authors: H.L. Del Puerto, A.S. Martins, L. Moro, A. Milsted, F. Alves, G.F. Braz and A.C. Vasconcelos
Canine distemper is an immunosuppressive disease caused by the canine distemper virus (CDV). Pathogenesis mainly involves the central nervous system and immunosuppression. Dogs naturally infected with CDV develop apoptotic cells in lymphoid tissues and the cerebellum, but this apoptotic mechanism is not well characterized. To .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr717
- DOI:
- 10.4238/vol9-1gmr717
Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism
Authors: M.D. Martello, N. David, R. Matuo, P.C. Carvalho, S.D. Navarro,A.C.D. Monreal, A.L. Cunha-Laura, C.A.L. Cardoso, C.A.L. Kassuya and R.J. Oliveira
Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027678
- DOI:
- 10.4238/gmr.15027678
Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells
Authors: N. Imir, E. Aydemir E. Simsek, R.S. Gokturk, E. Yesilada and K. Fiskin
We aimed to determine the cytotoxic and immunomodulatory effects of hydroalcoholic extracts of the roots and aerial parts of Ebenus boissieri (EB) on breast cancer MDA-MB231 cells and the non-cancerous human embryonic kidney cell line, 293T. Cell viability was determined by MTT assay, trypan blue exclusion, and Live/Dead Viabi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017766
- DOI:
- 10.4238/gmr.15017766
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Authors: M.Y. Yu, P.Q. Zhao, X.H. Yan, B. Liu, Q.Q. Zhang, R. Wang, C.H. Ma, X.H. Liang, F.L. Zhu and L.F. Gao
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recent.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.10.2
- DOI:
- 10.4238/2013.September.10.2
Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells
Authors: T.J. Xing, H.T. Xu, W.Q. Yu and D.F. Jiang
The regulation mechanism and significance of microRNA-122 (miRNA-122) expression are unclear. The aim of this study was to investigate the effects of DNA methylation on liver-specific miRNA-122 expression, cell proliferation, and apoptosis in hepatocellular carcinoma. Methylation of the miRNA-122 promoter region was detected through methylation sequencing.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.3
- DOI:
- 10.4238/2013.September.13.3
Effect of Ginkgo biloba extract on apoptosis of brain tissues in rats with acute cerebral infarction and related gene expression
Authors: C. Wu, X. Zhao, X. Zhang, S. Liu, H. Zhao and Y. Chen
We investigated the effect of Ginkgo biloba extract on apoptosis of brain tissues in rats with acute cerebral infarction and apoptosis-related gene expression. Rat models of acute cerebral infarction were constructed using the suture method, and randomly divided into the control group, model, and treatment groups. In the treatment group, 4 mg/kg G. biloba.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.14
- DOI:
- 10.4238/2015.June.11.14
Expression profiles of the apoptosis signaling pathway mediated by death receptor and endoplasmic reticulum in rat liver regeneration
Authors: X.K. Xing, M.H. Li, X.S. Zhu and C.S. Xu
The death receptor and endoplasmic reticulum (ER) are closely related to cell apoptosis, and it is worth studying whether the apoptosis pathways mediated by them are involved in liver regeneration. To understand the mechanism underlying death receptor- and ER-mediated apoptosis during rat liver regeneration, we used the Rat Ge.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028288
- DOI:
- 10.4238/gmr.15028288
Inhibition of subcutaneously implanted human pituitary tumor cells in nude mice by LRIG1
Authors: X. Wang, X.J. He, H.Q. Xu, Z.W. Chen and H.H. Fan
The aim of this study was to explore the inhibition of subcutaneously implanted human pituitary tumor cells in nude mice by LRIG1 and its mechanism. For this study, athymic nude mice were injected with either normal pituitary tumor RC-4B/C cells or LRIG1-transfected RC-4B/C cells. We then calculated the volume inhibition rate .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027681
- DOI:
- 10.4238/gmr.15027681
Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells
Authors: J.P. Li, Q. Ma and C.M. Chen
This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 act.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017490
- DOI:
- 10.4238/gmr.15017490
Effect of overexpression of PTEN on apoptosis of liver cancer cells
Authors: M.F. Li, H. Guan and D.D. Zhang
Liver cancer is a common malignant tumor associated with a short-survival period and high-mortality rate, and its prevalence in China is particularly high. This study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene on liver cancer cell apoptosis and prov.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028120
- DOI:
- 10.4238/gmr.15028120