Apoptosis
A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells
Authors: Y.H. Cao, D.G. Li, B. Xu1 M.Q. Wang, N. Zhen, L.X. Man,Y.Y. Zhang1 and M. Chi
Brain damage caused by perinatal asphyxia is dangerous for neonatal infants, but the mechanism by which it occurs remains elusive. In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027371
- DOI:
- 10.4238/gmr.15027371
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
FOXO1 is a tumor suppressor in cervical cancer
Authors: B. Zhang, L.S. Gui, X.L. Zhao, L.L. Zhu and Q.W. Li
Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in ce.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.3
- DOI:
- 10.4238/2015.June.18.3
STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis
Authors: Y.X. Wu, C.Z. Gao, K.L. Fan, L.M. Yang and X.F. Mei
Spinal cord injury (SCI) is typically caused by trauma or disease, and it severely affects patients’ motor function. The relationship between signal transducers and activators of transcription-1 (STAT1) and neuronal death after cerebral focal ischemia has been comprehensively studied, but its role in SCI remains largely .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017271
- DOI:
- 10.4238/gmr.15017271
Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique
Authors: D.F. Barione, F.S.N. Lizarte, P.C. Novais, C.A.M. de Carvalho, F.C.B. Valeri, F.M. Peria, H.F. de Oliveira, D.L. Zanette, W.A. Silva Jr., A.J. Cologna, R.B. Reis, S. Tucci Jr., A.C.P. Martins, D.P.C. Tirapelli and L.F. Tirapelli
We examined the expression of anti-apoptotic genes (XIAP and Bcl-2) and apoptotic genes (cytochrome c, caspase-9, Apaf-1) in tissue samples of patients with superficial bladder cancer. Thirty-two bladder cancer tissue samples (8 papillary urothelial neoplasm of low malignant potential, 10 low-grade, and 14 high-grade) and 8 normal bladder tissue samples f.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.4
- DOI:
- 10.4238/2013.April.2.4
MicroRNA-181b expression in prostate cancer tissues and its influence on the biological behavior of the prostate cancer cell line PC-3
Authors: L. He, H. Yao, L.H. Fan, L. Liu, S. Qiu, X. Li, J.P. Gao and C.Q. Hao
We examined microRNA-181b (miRNA) expression in prostate cancer tissues and its effect on the prostate cancer cell line PC-3. Tissues from 27 cases of prostate cancer and 30 samples of normal human prostate were collected by surgical removal. Total miRNA was extracted, and the relative expression of miR-181b was quantified using RT-PCR. miR-181b ASO was t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.17
- DOI:
- 10.4238/2013.April.2.17
The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction
Authors: V.C. Fernandes, S.I.V. Pereira, J. Coppede, J.S. Martins, W.F. Rizo, R.O. Beleboni, M. Marins, P.S. Pereira, A.M.S. Pereira and A.L. Fachin
Cancer has become the leading cause of death in developing countries due to increased life expectancy of the population and changes in lifestyle. Studies on active principles of plant have motivated researchers to develop new antitumor agents that are specific and effective for treatment of neoplasms. Kaurane diterpenes are considered important compounds .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.16
- DOI:
- 10.4238/2013.April.2.16
MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma
Authors: Y.B. Ma, D.W. Song, R.H. Nie and G.Y. Mu
MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uvea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027935
- DOI:
- 10.4238/gmr.15027935
Mechanisms of cytotoxicity induced by the anesthetic isoflurane: the role of inositol 1,4,5-trisphosphate receptors
Authors: W.-H. Zhai, J. Zhao, S.-P. Huo, X.-G. Chen, Y.-D. Li, Z.-L. Zhang, L.-L. Yu, S. Song and Q.-J. Wang
Isoflurane can induce widespread cytotoxicity. We hypothesized that isoflurane induces apoptosis partly by causing excessive calcium release from the endoplasmic reticulum (ER) via direct activation of inositol 1,4,5-trisphosphate receptors (IP3 R). Rat pheochromocytoma cells cultured for seven days with nerve growth factor were divided into four groups: .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.1
- DOI:
- 10.4238/2015.June.26.1
Protective effect of necrostatin-1 on myocardial tissue in rats with acute myocardial infarction
Authors: Y.R. Liu and H.M. Xu
The aim of this study was to investigate the protective effect of necrostatin-1 on myocardial tissue of acute myocardial infarction (AMI) rats and to provide a basis for necrostatin-1 for the treatment of acute myocardial infarction. AMI rats (45) were established by ligating the anterior descending branch of the left coronary.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027298
- DOI:
- 10.4238/gmr.15027298