Apoptosis
Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis
Authors: L.N. Xu, N. Lin, B.N. Xu, J.B. Li and S.Q. Chen
The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.2
- DOI:
- 10.4238/2015.December.11.2
Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer
Authors: Y.H. Liu and W.L. Zhu
In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.12
- DOI:
- 10.4238/2015.December.11.12
Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair
Authors: B.Y. Zhang, Z. Zhao and Z. Jin
Myocarditis is a common cardiovascular disease and frequently occurs in children and teenagers. It is believed to be caused by both endogenous and exogenous factors, among which FAS/FASL gene pair-induced cell apoptosis is a major mechanism of myocardial cell injury. A previous study has detected low expression of microRNA (mi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027627
- DOI:
- 10.4238/gmr.15027627
Effects of lentiviral short hairpin RNA silencing of Toll-like receptor 4 on the lens epithelial cell line HLEC
Authors: H.T. Yu and P.R. Lu
The aim of this study was to observe the proliferation of, and cell-cycle changes in, the human lens epithelial cell line HLEC after Toll-like receptor 4 (TLR4) gene silencing. HLEC cells were transfected with four TLR4-short hairpin RNA (shRNA) lentiviral vectors or the control lentivirus (pGCL-GFP-shRP-1, -2, -3, -4, NC). TL.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027897
- DOI:
- 10.4238/gmr.15027897
Effect of baculovirus P35 protein on apoptosis in brain tissue of rats with acute cerebral infarction
Authors: J.F. Ji and X.H. Ma
We explored the effect of baculovirus P35 protein on apoptosis in the brain tissue of rats with acute cerebral infarction (ACI). A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model, and treatment groups. Baculovirus P35 protein was injected into the intracranial arteries of the treatment group rats.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.16
- DOI:
- 10.4238/2015.August.10.16
MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG
Authors: J.J. Li,W.H. Chan,W.Y. Leung,Y. Wang and C.S. Xu
Rat liver regeneration (RLR) induced by partial hepatectomy involves cell proliferation regulated by numerous factors, including microRNAs (miRNAs). miRNA high-throughput sequencing has been established and used to analyze miRNA expression profiles. This study showed that 39 miRNAs were related to RLR through the analysis of miRNA high-throughput sequenci.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.30
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.30
Expression and effect of serum interleukin-24 level on bone marrow mononuclear cells in children with acute leukemia
Authors: H.R. Cheng, B.Q. Wu, L. Chen, Z.X. Zhang and B. Li
To investigate the expression of interleukin-24 (IL-24) in the children with acute leukemia (AL) and its effect on the apoptosis of bone marrow mononuclear cells (BMMNCs) in vitro. Four groups were assessed: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), non-leukemia, and healthy groups, 20 children in each group. ELISA was used to measur.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.28
- DOI:
- 10.4238/2015.December.16.28
Mechanism of rat osteosarcoma cell apoptosis induced by a combination of low-intensity ultrasound and 5-aminolevulinic acid in vitro
Authors: Y.N. Li, Q. Zhou, B. Yang, Z. Hu, J.H. Wang, Q.S. Li and W.W. Cao
We investigated the killing effect of low-intensity ultrasound combined with 5-aminolevulinic acid (5-ALA) on the rat osteosarcoma cell line UMR-106. Logarithmic-phase UMR-106 cells were divided into a control group, ultrasound group and 5-ALA group. The cell apoptotic rate, production of reactive oxygen species, and the change in mitochondrial membrane p.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.23
- DOI:
- 10.4238/2015.August.14.23
Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction
Authors: Y.Y. Qiu, Y. Chen, T.H. Zeng, W.H. Guo, W.Y. Zhou and X.J. Yang
Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027755
- DOI:
- 10.4238/gmr.15027755
Aquaporin in the proliferation and apoptosis of diabetic myocardial cells
Authors: P.F. Zhao and M.J. Sun
The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis. The methylthiazolyle tetrazolium assay was used to detect the inhibitory effect of different concentrations of aquaporin on cell growth. The rate of aquaporin-induced myocardial cell apoptosis was detected by flow cytometric.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.5
- DOI:
- 10.4238/2015.December.21.5