Apoptosis
Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis
Authors: T.F. Huang, X.H. Wu, X. Wang and I.J. Lu
The aim of the current study was to investigate Fas and FasL expression and myocardial cell apoptosis in viral myocarditis patients. Human heart specimens were selected from patients who were autopsied between February 2012 and February 2015; of these, 25 patients were diagnosed with viral myocarditis. Another 15 cases with no.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027607
- DOI:
- 10.4238/gmr.15027607
O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines
Authors: G.G.N. de S. Wisintainer, G. Scola, S. Moura, T.L.G. Lemos, C. Pessoa, M.O. de Moraes, L.G.S. Souza, M. Roesch-Ely and J.A.P. Henriques
Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analysis. The cytotoxicity was further evaluated exclusively for 48 h of treatment in different tumor and non-tu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.18
- DOI:
- 10.4238/2015.December.21.18
Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax
Authors: Y. Wei1, F.J. Yuan, W.B. Zhou, L. Wu, L. Chen, J.J. Wang and Y.S. Zhang
Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlyin.. Read More»
- Genet. Mol. Res. 15(2):
Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling
Authors: Q. Song, Y.L. Ma, J.Q. Song, Q. Chen, G.S. Xia, J.Y. Ma, F. Feng, X.J. Fei and Q.M. Wang
Sevoflurane, the most widely used anesthetic in clinical practice, has been shown to induce apoptosis, inhibit neurogenesis, and cause learning and memory impairment in young mice. However, the underlying mechanism is still unknown. In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure ox.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.32
- DOI:
- 10.4238/2015.December.22.32
Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells
Authors: R.F. Liu, F. Wang, Q. Wang, X.C. Zhao and K.M. Zhang
Psoriasis is an inflammatory skin disease characterized by excessive proliferation and abnormal differentiation and apoptosis of keratinocytes (KCs). Mesenchymal stem cells (MSCs) from skin lesions of psoriasis patients demonstrate abnormal cytokine secretion, which may affect KC proliferation and apoptosis. Here, we explored how MSCs from skin lesions of.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.49
- DOI:
- 10.4238/2015.December.21.49
Acute toxic effects of sonodynamic therapy on hypertrophic scar fibroblasts of rabbit ears
Authors: W. Li,J.F. Fei1,Q. Yang,B.L. Li,C. Lin,Q. Yue and Q.G. Meng
The objective of this study was to observe the acute cytotoxic effects of hematoporphyrin monomethyl ether sonodynamic therapy (HMME-SDT) on hypertrophic scar fibroblasts of rabbit ears. We first assessed the effects of different irradiation times and HMME concentrations on the survival of hypertrophic scar fibroblasts using the 3-(4,5-dimethylthiazol-2-y.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.3
Establishment of a blue light damage model of human retinal pigment epithelial cells in vitro
Authors: G. Su, S.J. Cai, X. Gong, L.L. Wang, H.H. Li and L.M. Wang
To establish a blue-light damage model of human retinal pigment epithelium (RPE). Fourth-generation human RPE cells were randomly divided into two groups. In group A, cells were exposed to blue light (2000 ± 500 lux) for 0 (control), 3, 6, 9, and 12 h, and cell culture was stopped after 12 h. In group B, cells were expo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028092
- DOI:
- 10.4238/gmr.15028092
miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-�ºB pathway
Authors: Z.W. Wu, Y.F. Liu, S. Wang and B. Li
The aim of this study was to investigate the role of miRNA-146a in modulating the function of vascular smooth muscle cells in a rat model of coronary heart disease. Vascular smooth muscle cells were isolated and cultured from the rat coronary heart disease model and normal rats (controls). miRNA-146a levels were measured in vascular smooth muscle cells ob.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.19
- DOI:
- 10.4238/2015.December.28.19
Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes
Authors: Y. Yang, Y. Zhou, S. Cheng, J.L. Sun, H. Yao and L. Ma
Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured in vitro were treated with varying concentrations of UA. The change in apoptotic activity was detected by flow cytometry. The DNA damage index 8-hydroxy-deoxy-guanosine (8-OHdG) and mitochondrial function indices succinate dehyd.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028644
- DOI:
- 10.4238/gmr.15028644
Effect and mechanism of miR-126 in myocardial ischemia reperfusion
Authors: B. Li, Y. Tao and Q. Huang
Multiple studies have shown microRNAs to play an important role in disease occurrence and development. The role of miRNAs in ischemia-reperfusion injury, however, requires further investigation and the aim of this study was therefore to assess miR-126 expression in myocardial ischemia reperfusion and the effects of miR-126 on myocardial ischemia-reperfusi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.6
- DOI:
- 10.4238/2015.December.29.6