Apoptosis
Role of salubrinal in protecting cardiomyocytes from doxorubicin-induced apoptosis
Authors: N. Gong, J.H. Wu, Z.S. Liang, W.H. Jiang and X.W. Wang
We determined whether salubrinal can protect cardiomyocytes from doxorubicin-induced apoptosis and explored the related mechanisms to provide experimental evidence for exploring novel drug candidates to decrease cardiac toxicity. Neonatal rat cardiomyocytes were isolated, cultured in vitro, and pretreated with salubrinal .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.4
- DOI:
- 10.4238/2015.October.16.4
Effect of Bcl-2-siRNA on proliferation and apoptosis of pediatric acute B lymphoblastic leukemia (A-BLL) cells
Authors: W.B. Meng, J.P. Liu, X.W. Wang and L.H. E
This study analyzed the effect of small interfering RNA specific for the Bcl-2 gene (siRNA Bcl-2) on the proliferation and chemotherapeutic sensitivity of pediatric A-BLL cells. Marrow samples were obtained from sixty newly-diagnosed A-BLL pediatric patients. The Bcl-2 mRNA expression in these samples was quantified by real ti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.9
- DOI:
- 10.4238/2015.October.16.9
Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore
Authors: T. Song, J. Liu, X. Tao and J.G. Deng
The aim of this study was to investigate the influence of atorvastatin on the opening of the mitochondrial permeability transition pore (MPTP) and the expression of cytochrome C (Cyt C) in Sprague-Dawley rats with cerebral ischemia-reperfusion (I/R). The rat model of cerebral artery ischemia was established by the suture-occluded method with ischemia for .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.5
- DOI:
- 10.4238/2014.December.18.5
Changes in cFLIP expression in the corpus luteum throughout the estrous cycle of Shibagoats
Authors: H.Z. Jin, Y. Wang, Y. Liu, X.P. Li and Y. Jin
Changes in the expression of the anti-apoptotic protein cFLIP (cellular FLICE inhibitory protein) were examined in the caprine corpus luteum (CL), during development and subsequent maintenance. Corpora lutea at four different stages were collected from Shiba goats, to measure the expression of cFLIP mRNA, protein and immunolocalization. Expression of shor.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.16
- DOI:
- 10.4238/2015.October.21.16
Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro
Authors: M. Yue, X.J. Shen, Y.X. Liu, X.Y. Lin, S.Q. Zhou and Y.H. Song
Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We inve.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.12
- DOI:
- 10.4238/2015.November.30.12
MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5
Authors: T.K. Li, K. Yin, Z. Chen, Y. Bao and S.X. Zhang
Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bio.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019327
- DOI:
- 10.4238/gmr16019327
Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells
Authors: E.��. U�§ar N. Arda A. Aitken
Extracts of mistletoe (Viscum album) are intensively used in complementary medicine, but their mechanisms are not fully understood in most cases, and the effects on metabolism have not been investigated in detail. However, some biologically active natural products are well known to provoke unexpected cellular responses. They reduce overexpression of heat .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.5
- DOI:
- 10.4238/2012.August.24.5
Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer
Authors: Y. Shen, Y.F. Ye, L.W. Ruan, L. Bao, M.W. Wu and Y. Zhou
Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019479
- DOI:
- 10.4238/gmr16019479
Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells
Authors: H.-J. Cao, M.-D. Wang, S.-G. Li, L. Zhu, J.-H. Zheng
We investigated the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) on the proliferation, apoptosis, and alpha-actin-2 (ACTA2) expression of hepatic stellate cells (HSCs), and explored the possible mechanisms of hepatocyte growth factor (HGF). We established a co-culture system by culturing BMSCs on the upper layer and HSCs on the lower la.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019201
- DOI:
- 10.4238/gmr16019201
Cytotoxicity of 1-dodecyl-3-methylimidazolium bromide on HepG2 cells
Authors: T.H. Li, C.Q. Jing, K.L. Gao, W.Y. Yue and S.F. Li
We evaluated the cytotoxicity of 1-dodecyl-3-methylimidazolium bromide ([C12mim][Br]) on HepG2 cells and its influence on plasma membrane permeability. The results showed that [C12mim][Br] inhibited HepG2 cell growth and decreased cell viability in a concentration-dependent manner. The results also revealed that [C12mim][Br] exposure induced apoptosis in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.31
- DOI:
- 10.4238/2015.October.26.31