Apoptosis
Protective mechanism of quercetin on acute myocardial infarction in rats
Authors: B. Li M. Yang J.W. Liu G.T. Yin
To investigate the protective mechanism of quercetin on acute myocardial infarction (AMI) rats, an AMI rat model was established by ligating the left coronary anterior descending branch. The rats were randomly divided into the model group and low- and high-dose quercetin groups. The control group comprised sham-operated rats. The rats in the low- and high.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017117
- DOI:
- 10.4238/gmr.15017117
Lenalidomide affect expression level of cereblon protein in multiple myeloma cell line RPMI8226
Authors: D.Y. Yang, J.H. Ren, X.N. Guo, X.L. Guo, X.Y. Cai, X.F. Guo and J.N. Zhang
We investigated the mechanisms of action of immunomodulatory drug (lenalidomide) on the protein expression of cereblon (CRBN) and their therapeutic targets in the multiple myeloma cell line RPMI8226. The multiple myeloma cell line RPMI8226 was cultured and treated with different concentrations of lenalidomide and bortezomib to determine the proliferation .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.19
- DOI:
- 10.4238/2015.October.28.19
Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells
Authors: Y. Deng, J. Sun and L.D. Zhang
The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody wa.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016826
- DOI:
- 10.4238/gmr.15016826
5-Fluorouracil induces apoptosis of colorectal cancer cells
Authors: J.T. Zhang1, W.L. Zhou2, C. He3, T. Liu1, C.Y. Li1 and L. Wang1
5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017326
- DOI:
- 10.4238/gmr.15017326
Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion
Authors: T.Y. Liu1, H. Zhang2, S.M. Du3, J. Li1 and X.H. Wen1
This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control grou.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017746
- DOI:
- 10.4238/gmr.15017746
Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway
Authors: Z.G. Peng1, D.C. Liu2, Y.B. Yao1, X.L. Feng3, X. Huang1, Y.L. Tang1, J. Yang1 and X.X. Wang1
Paclitaxel (PTX) is a mitotic inhibitor widely used in chemotherapy for many types of cancers, including solid tumors and hematological malignancies. However, the molecular basis of the anti-proliferation activity of PTX is not fully understood. In this paper, we focused on the role of c-Jun N-terminal kinase (JNK) pathways in PTX-induced apoptosis and pr.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15013904
- DOI:
- 10.4238/gmr.15013904
Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells
Authors: F.J. Ji, X.F. Tian, X.W. Liu, L.B. Fu, Y.Y. Wu, X.D. Fang,H.Y. Jin
The aim of the present study was to determine the antiproliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), la.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.7
- DOI:
- 10.4238/2015.December.1.7
Anticancer activity of Bombyx batryticatus ethanol extract against the human tumor cell line HeLa
Authors: W.P. Wu, J. Cao, J.Y. Wu, H. Chen and D. Wang
Anticancer activity of Bombyx batryticatus ethanol extract (BBE) against HeLa cells was studied using cell viability, DNA fragmentation, real-time polymerase chain reaction, and Western blot analyses. The BBE inhibited the growth and induced apoptosis of HeLa cells. The MTT assay indicated that the BBE induced cytotoxicity in HeLa cells in a time- and con.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.10
- DOI:
- 10.4238/2015.January.15.10
Mitochondria-dependent apoptogenic activity of the aqueous root extract of Croton membranaceus against human BPH-1 cells
Authors: D.K. Afriyie, G.A. Asare, K. Bugyei, J. Lin, J. Peng and Z. Hong
The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphis.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.18
- DOI:
- 10.4238/2015.January.15.18
miR-187 induces apoptosis of SiHa cervical carcinoma cells by downregulating Bcl-2
Authors: C.Y. He and J. Yang
Cervical carcinoma is a life-threatening illness posing considerable danger to women’s health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018969
- DOI:
- 10.4238/gmr16018969