Apoptosis
Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy
Authors: L. Ren1*, R. Zhu2* and X. Li1
Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with pote.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017798
- DOI:
- 10.4238/gmr.15017798
Correlation of acetabular chondrocyte apoptosis with caspase-3 and Bcl-2 expression in developmental dislocations of the hip
Authors: L.J. Ding, Y.L. Liu, G. Ma, Y.Q. Jia, Y.S.H. Wei and X.M. Liu
This study aimed to determine whether abnormal apoptosis is present in acetabular cartilage in early developmental dislocations of the hip (DDH), and if so, whether it is correlated with the expression of caspase-3 and Bcl-2. DDH was induced in 24 4-week-old New Zealand white rabbits. Acetabular cartilage specimens from the experimental and control groups.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036809
- DOI:
- 10.4238/gmr.15036809
Apoptosis in different gastric lesions and gastric cancer: relationship with Helicobacter pylori, overexpression of p53 and aneuploidy
Authors: A.C. Targa, A.C.G. C�©sar, P.M. Cury, A.E. Silva
Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal metaplasia, and stomach tumorigenesis. Thus, the aim of the present study was to investigate the frequency of ap.. Read More»
- Genet. Mol. Res. 6(3):
Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells
Authors: D.X. Li, J. Zhang, Y. Zhang, P.W. Zhao and L.M. Yang
Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-depe.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.17
Effects of the ginkgo biloba extract on the superoxide dismutase activity and apoptosis of endothelial progenitor cells from diabetic peripheral blood
Authors: M. Zhao, X.-X. Wang and W.-H. Wan
Although ginkgo biloba extract (GBE) was shown to have antioxidant effects, little has been reported on the ability to GBE to help endothelial progenitor cells (EPCs) resist oxidative stress. The present study evaluated the influence of different concentrations of GBE on superoxide dismutase (SOD) and apoptosis of diabetic per.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.1
- DOI:
- 10.4238/2014.January.14.1
Marsdenia tenacissima extract sensitizes MG63 cells to doxorubicin-induced apoptosis
Authors: T. Huang, W.H. Gong, C.P. Zou, X.C. Li, G.J. Jiang, X.H. Liand H. Qian
Marsdenia tenacissima extract (MTE) is a new plate-derived biotechnology product that is frequently used, but occasionally reported, in the field of chemotherapy. In this study, we assessed the antitumor activity and related mechanisms of MTE by various biotechnological methods. The survival rates of MG63 osteosarcoma cells tr.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.21.3
- DOI:
- http://dx.doi.org/10.4238/2014.January.21.3
Vero cells infected with the Lederle strain of canine distemper virus have increased Fas receptor signaling expression at 15 h post-infection
Authors: H.L. Del Puerto, A.S. Martins, G.F. Braz, F. Alves, M.B. Heinemann, D.S. Raj�£o, F.C. Ara�ºjo, S.F. Martins, D.R. Nascimento, R.C. Leite and A.C. Vasconcelos
We evaluated the expression of the Fas receptor gene in Vero cells infected with the Lederle vaccine strain of canine distemper virus using RT-PCR. Vero cells were plated, and after being grown for 24 h in MEM with 5% FBS, 80-90% confluent monolayer cultures were infected with the virus. The cells were harvested at 3, 6, 9, an.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.18.3
- DOI:
- 10.4238/2011.October.18.3
Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats
Authors: C. Liu, J. Cai, Z. Cheng, X. Dai, L. Tao, J. Zhang and D. Xue
Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.15
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.15
Wnt/�²-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1
Authors: B.Q. Cheng, Y. Jiang, Q. Zhu and W.G. Lin
Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/β-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our re.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.4
- DOI:
- 10.4238/2014.July.7.4
Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells
Authors: Y.P. Zhang, Y.Q. Li, Y.T. Lv and J.M. Wang
Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentratio.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.9
- DOI:
- 10.4238/2015.February.6.9