Apoptosis
Effect of p53 gene polymorphism on functions of prostate cancer cells
Authors: N. Chi, Z.Z. Yun, Z.H. Tan, X.Z. Li, B.T.B.G. Chen, J. Liu, L.B. Xu, K.W. Ma, S.X. Li, J.F. Liu and C.X. Liu
Prostate cancer cells were transfected with plasmids [empty plasmids, wild-type pcDNA3.1-p53 (V/V), mutant type pcDNA3.1- p53 (G/G)] to analyze the effect of p53 gene polymorphisms on the proliferation, cycle, and apoptosis of prostatic cancer cells. Empty plasmids containing wild-type pcDNA3.1-p53 (V/V) and mutant type pcDNA3.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.3
- DOI:
- 10.4238/2015.October.2.3
Influence of Arg72Pro polymorphisms of TP53 on the response of buccal cells to radiotherapy.
Authors: L. Pereira, M.R.S. Carvalho, C.G. Fonseca, S.S.S. Lima, E.M.M. Cerqueira, W. Jorge and M.C.L. Castro
Polymorphisms in the TP53 gene codon 72 (Arg72Pro) influence apoptosis induction and DNA damage repair. We evaluated how variants of protein p53 (p53Arg and p53Pro) affect cell death and DNA damage repair by analyzing the frequencies of karyorrhexis and micronuclei. There were significant differences in the frequency of karyor.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.6
- DOI:
- 10.4238/2011.December.14.6
Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway
Authors: B. Ni, F.F. Bai, Y. Wei, M.J. Liu, Z.X. Feng, Q.Y. Xiong, L.Z. Hua and G.Q. Shao
Lipid-associated membrane proteins (LAMPs) are important in the pathogenicity of the Mycoplasma genus of bacteria. We investigated whether Mycoplasma hyopneumoniae LAMPs have pathogenic potential by inducing apoptosis in a St. Jude porcine lung epithelial cell line (SJPL). LAMPs from a pathogenic strain of M. hyopneumoniae (strain 232) were used in the re.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.25.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.25.10
Ulinastatin promotes T lymphocyte apoptosis in rats with severe acute pancreatitis via mitochondrial pathways
Authors: C.L. Wang, N. Li, T. Ma, P. Zhang and S.Y. You
We explored the influence of ulinastatin on apoptosis of T lymphocytes in rats with severe acute pancreatitis (SAP) and the effect of ulinastatin on mitochondrial apoptosis pathways in spleen lymphocytes. Thirty-six Wistar rats were randomly divided into three groups (N = 12): a sham operated group, a SAP group, and an ulinastatin-treated SAP group. The S.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.2
- DOI:
- 10.4238/2015.May.25.2
Forkhead box protein O1 mediates apoptosis in a cancer cervical cell line treated with the antitumor agent tumor necrosis factor-�±
Authors: B. Zhang, L. Gui, L. Zhu, X. Zhao, Y. Yang and Q. Li
Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptos.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.20
- DOI:
- 10.4238/2015.July.3.20
Effects of acrylonitrile on the pathological morphology and apoptosis of neurons in rats
Authors: C.Z. Li, L.A. Tse, Y.L. Zhou, W. Fan, M. Li, I.T.S. Yu and T.Y. Jin
This study aimed to evaluate the effects of acrylonitrile (ACN) on neuronal morphology and apoptosis in rats. An ACN solution was administered to Wistar rats by gavage at doses of 0, 5, 10, or 20 mg/kg, 5 days a week for 13 weeks. The morphology of neurons and the presence of apoptosis was examined by light and electron micros.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.29.7
- DOI:
- 10.4238/2014.July.29.7
Mechanism of the reversal effect of mifepristone on drug resistance of the human cervical cancer cell line HeLa/MMC
Authors: H. Chen, J. Duan and F. Zuo
We examined the ability of mifepristone to reverse the in vitro drug resistance of human cervical cancer cells resistant to mitomycin-C (HeLa/MMC) cells and investigated the mechanism of this effect. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to detect the drug resistance of HeLa/MMC cel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.27.14
- DOI:
- http://dx.doi.org/10.4238/2014.February.27.14
Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line
Authors: Y. Xia, X.L. Zhang, F. Jin, Q.X. Wang, R. Xiao, Z.H. Hao, Q.D. Gui and J. Sun
The objective of this study was to investigate the effect of sodium acetate on the viability of the human gastric adenocarcinoma (AGS) epithelial cell line. AGS cells were exposed to a range of concentrations of sodium acetate for different periods of time, and the sodium acetate-induced cytotoxic effects, including cell viabi.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048375
- DOI:
- 10.4238/gmr.15048375
Evidence of programmed cell death during microsporogenesis in an interspecific Brachiaria (Poaceae: Panicoideae: Paniceae) hybrid
Authors: Fuzinatto VA, Pagliarini MS and Valle CB
Morphological changes have been investigated during plant programmed cell death (PCD) in the last few years due to the new interest in a possible apoptotic-like phenomenon existing in plants. Although PCD has been reported in several tissues and specialized cells in plants, there have been few reports of its occurrence during .. Read More»
- Genet. Mol. Res. 6(2):
Effect of TIEG1 on apoptosis and expression of Bcl-2/Bax and Pten in leukemic cell lines
Authors: K. Yao, H.C. Xing , B. Wu, Y. Li , A.J. Liao, W. Yang and Z.G. Liu
We examined the effect of transforming growth factor-b inducible early gene-1 (TIEG1) on the apoptosis of leukemic cell lines and expression of B-cell lymphoma 2 (Bcl-2) and phosphatase and tensin homolog (Pten). Four leukemic cell lines (HL-60, U937, Raji, and K562) were treated with 0, 1, 5, 10, and 20 ng/mL TIEG1, respectively. The cell growth.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.6
- DOI:
- 10.4238/2015.March.20.6