Apoptosis
Neuroprotective effects of Bcl-2 overexpression on nerve cells of rats with acute cerebral infarction
Authors: H.R. Zhang, J.H. Peng, G.Y. Zhu and R.X. Xu
We aimed to investigate the influence of lentiviral-mediated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.15
- DOI:
- 10.4238/2015.July.13.15
Effect of hydroxy safflower yellow A on myocardial apoptosis after acute myocardial infarction in rats
Authors: M.X. Zhou, J.H. Fu, Q. Zhang and J.Q. Wang
This study aimed to investigate the effect of hydroxy safflower yellow A (HSYA) on myocardial apoptosis after acute myocardial infarction (AMI) in rats. We randomly divided 170 male Wistar rats into 6 groups (N = 23): normal control, sham, control, SY (90 mg/kg), HSYA high-dose (HSYA-H, 40 mg/kg), and HSYA low-dose groups (HSYA-L, 20 mg/kg). Myocardial is.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.24
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.24
Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose
Authors: Z.P. Feng, H.C. Deng, R. Jiang, J. Du and D.Y. Cheng
We investigated the effect of p38MAPK/AP-1 (activator protein-1) signaling on the apoptosis of osteoblasts induced by high glucose. A lentivirus vector of small hairpin RNA (shRNA) targeting p38MAPK was constructed in vitro. Osteoblasts MC3T3-E1 cultured in vitro were treated with vehicle, high glucose, p38MAPK-shRNA transfection, p38MAPK inhibitor, and u.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.26
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.26
Study of the radiotherapy sensitization effects and mechanism of capecitabine (Xeloda) against non-small-cell lung cancer cell line A549
Authors: J.J. Zhu, J.J. Shan, L.B. Sun1 and W.S. Qiu
The purpose of this study was to explore the radiotherapy sensitization effects and the mechanism of capecitabine (Xeloda) against the non-small-cell lung cancer cell line, A549. γ-[60Co] radiation was used as the intervention method. Proliferative inhibition of capecitabine on A549 cells was determined by the CCK-8 method. The effects of capecitabi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Influence of chitosan nanoparticle-mediated C-erbB-2 gene silencing on invasion and apoptosis of Hep-2 cells
Authors: W.R. Liu, L.R. Cao and G.J. Zuo
We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048860
- DOI:
- 10.4238/gmr15048860
Cell proliferation and apoptosis in the fetal and neonatal ovary of guinea pigs
Authors: S.Y. Sun, W. Zhang, X. Han, R.H. Huang and F.X. Shi
The guinea pig is an excellent animal model for studying reproductive biology of adult humans and most domestic animals. Yet, whether this animal might serve as a good model for embryonic stage investigations and determinations of signals affecting or directing ovary development remains unknown. These questions were addressed .. Read More»
- Genet. Mol. Res. 13(1):
Histone H3K9 acetylation influences growth characteristics of goat adipose-derived stem cells in vitro
Authors: X. Wang, F.X. Zhang, Z.M. Wang, Q. Wang, H.F. Wang, Y. Ren,D.P. Tai, H. Liang and D.J. Liu
Adipose-derived stem cells (ADSCs) show nearly unlimited potential in medical and animal science. Currently, understanding of the biological mechanisms regulating ADSC growth in vitro remains very limited. Histone acetylation, an epigenetic modification, plays a key role in maintaining stem cell properties. To further study it.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048954
- DOI:
- 10.4238/gmr15048954
Micronuclei as biomarkers for evaluating the risk of malignant transformation in the uterine cervix
Authors: G.M.A. Aires, J.R.C. Meireles, P.C. Oliveira, J.L. Oliveira, E.L. Ara�ºjo, B.C. Pires, E.S.A. Cruz, N.F. Jesus, C.A.B. Pereira and E.M.M. Cerqueira
We evaluated micronucleus and apoptosis occurrence among women with normal smears and women with different kinds of cervical abnormalities, i.e., inflammatory processes and low- and high-grade squamous intraepithelial lesions (N = 12, N = 10 and N = 27, respectively). The sample included 59 women who were seen at a public medi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1156
- DOI:
- 10.4238/vol10-3gmr1156
Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats
Authors: W. Tian, L. Chen, L. Zhang, B. Wang, X.B. Li, K.R. Fan, C.H. Ai, X. Xia, S.D. Li, Y. Li
Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, e.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019463
- DOI:
- 10.4238/gmr16019463
Expression and localization of cFLIP anti-apoptotic protein in the porcine corpus luteum and corpora albicans during the estrous cycle and pregnancy
Authors: H.Z. Jin, W.S. Shi, Y. Tian, Y. Liu, Y. Jin and N. Manabe
We determined expression and localization of the anti-apoptotic cellular FLICE inhibitory protein (cFLIP) in the porcine corpora lutea (CL) and corpus albicans (CA) during estrous and pregnancy. The CL and CA were collected at different stages of estrous to determine cFLIP immunolocalization, and mRNA and protein expression. The mRNA expression of the sho.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.14
- DOI:
- 10.4238/2015.July.27.14