Biomarker
The clinical significance of miR-7-5p downregulation in gastric dysplasia and gastric cancer tissue
Authors: Sara Omrani, Ali Zare, Shahriar Tarighi, Hamid Ghaedi, Mir Davood Omrani
miRNAs have been involved in the pathogenesis of several cancers such as gastric cancer (GC.). In the following study we analyzed the expression of miR-7 in gastric cancer samples compared non-tumor tissues and gastric dysplasia (GD) samples with patients’ clinico-pathological data and its potential as diagnostic biomarker. We first analyzed its exp.. Read More»
- Genet. Mol. Res. 18(4):
MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection
Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro
Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039933
- DOI:
- http://dx.doi.org/10.4238/gmr16039933
DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer
Authors: T.D. Silva, A.V. Felipe, V.M. Vidigal, S.S. Saad, N.M. Forones
Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissu.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039816
- DOI:
- 10.4238/gmr16039816
A novel TET2 mutation in a patient with refractory cytopenia with multilineage dysplasia
Authors: D.F. Coutinho, C. Diniz, R.L.D. Filgueiras, R.L.R. Baptista,J.P. Ayres-Silva, B.C.R. Monte-M�³r, M.H. Bonamino, I.R. Zalcberg
Myelodysplastic syndrome diagnosis of karyotypically normal patients may be elusive because it relies exclusively on morphological and clinical data. In routine practice, finding of an acquired mutation or a cytogenetic abnormality provides irrefutable evidence of the clonal nature of that disease. Recurrent deletions and soma.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.13
- DOI:
- 10.4238/2013.November.22.13
Analysis of protein-protein interaction network in chronic obstructive pulmonary disease
Authors: Y.P. Yuan, Y.H. Shi and W.C. Gu
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for .. Read More»
- Genet. Mol. Res. 13(4):
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma
Authors: H.T. Niu, X.J. Qi, Y.Q. Liu, Y.W. Cao, Q. Dong and X.S. Wang
To bring about improvements in cancer biology research and elucidate mechanism-based therapeutic targets, we studied the proteome expression profile of purified normal urothelial cells (cancer cells) and normal stromal cells (cancerous stromal cells). Based on the expression profile, biomarker discovery and the mechanisms of multi-step carcinogenesis were.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.28
- DOI:
- 10.4238/2013.February.28.28
Development of novel DNA markers for genetic analysis of grey hamsters by cross-species amplification of microsatellites
Authors: C. Wang1,2*, S.J. Zhang1*, X.Y. Du1, Y.M. Xu3, X.Y. Huo1, L.F. Liao3 and Z.W. Chen1
The grey hamster has been used in biomedical research for decades. However, effective molecular methods for evaluating the genetic structure of this species are lacking, which hinders its wider usage. In this study, we employed cross-amplification of microsatellite loci of species within the same genus by polymerase chain reaction. Loci screened included .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.19
- DOI:
- 10.4238/2015.November.13.19
Weak cation magnetic separation technology and MALDI-TOF-MS in screening serum protein markers in primary type I osteoporosis
Authors: X.L. Shi, C.W. Li, B.C. Liang, K.H. He and X.Y. Li
We investigated weak cation magnetic separation technology and matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) in screening serum protein markers of primary type I osteoporosis. We selected 16 postmenopausal women with osteoporosis and nine postmenopausal women as controls to find a .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.4
- DOI:
- 10.4238/2015.November.30.4
Serum proteomic spectral characteristics of acute myeloid leukemia and their clinical significance
Authors: R.-J. Zheng, R.-J. Wu and X.-D. Ma
We investigated the differences between the serum proteomic spectral characteristics of acute myeloid leukemia (AML) patients and those of healthy people. We collected peripheral blood serum samples from 62 AML patients and 15 healthy controls. After removing high-abundance proteins, low-abundance serum proteins were separated.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029172
- DOI:
- 10.4238/gmr16029172
Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer
Authors: Z.Q. Wang,X.L. Sun,H.L. Su,X.F. Liu,Y.J. Xuan,S.Q. Yu
We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.5
- DOI:
- 10.4238/2015.December.1.5