Biomarker
Proteomic analysis of non-tumoral breast tissue
Authors: G.G. Costa, R. Kaviski, L.E.R. Souza, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is a complex and heterogeneous disease. In spite of the advances made in recent decades, a better understanding of the intrinsic mechanisms of this disease is crucial. The development of new biomarkers is absolutely necessary to improve diagnosis and prognosis. Research using the proteomic approach has generated .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.3
- DOI:
- 10.4238/2011.October.3.3
Serum miR-200c expression level as a prognostic biomarker for gastric cancer
Authors: H.-P. Zhang,F.-B. Sun, S.-J. Li
The aim of the present study was to analyze the serum expression level of microRNA-200c (miR-200c) in gastric cancer (GC) patients and to determine the relationship between this expression and clinicopathological features and survival. Serum samples were obtained from 98 patients with GC between February 2008 and January 2013... Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.2
- DOI:
- 10.4238/2015.December.7.2
Prognostic role of microRNA-100 in patients with bladder cancer
Authors: Y.H. Cao, H.H. Zhang,H.F. Xu, Y.J. Duan, Q. Li, B. Huang
We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the K.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.6
- DOI:
- 10.4238/2015.December.7.6
Study on serum proteomic features in patients with and without recurrence or metastasis after surgical resection of esophageal carcinoma
Authors: G.B. Zheng, C.F. Gao, X.L. Wang, G. Zhao and D.H. Li
The purpose of this study was to identify specific biomarkers for recurrence or metastasis of esophageal carcinoma in serum of patients subjected to esophagectomy. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) combined with IMAC-Cu2+ ProteinChip array were performed for the serum .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.23
- DOI:
- 10.4238/2014.January.21.23
Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery
Authors: X.-X. Liu and F.-J. Liu
Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tiss.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.14
- DOI:
- 10.4238/2015.May.4.14
Plasma human mammaglobin mRNA associated with poor outcome in patients with breast cancer
Authors: G.-W. Lee J.-Y. Kim E.-H. Koh D. Kang D.S. Choi K.-Y. Maeng J.-S. Lee
Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determin.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.28.2
- DOI:
- 10.4238/2012.November.28.2
Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang
Authors: L. Zhang, J. Sun, J.Q. Zhang, M. Yang, G. Bai and X.L. Ma
This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esoph.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.21
- DOI:
- 10.4238/2014.July.24.21
Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis
Authors: S.R. Yan, Z.J. Liu, S. Yu and Y.X. Bao
The diagnostic and prognostic value of miR-21 has been examined for hepatocellular carcinoma (HCC), with inconsistent results. Present meta-analysis summarized the diagnostic accuracy and the predictive role for survival of miR-21 in patients with HCC. All eligible studies were searched using PubMed, EMBASE, and Chinese National Knowledge Infrastructure (.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.9
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.9
Expression of microRNA-106b and its clinical significance in cutaneous melanoma
Authors: N. Lin, Y. Zhou, X. Lian and Y. Tu
MicroRNA-106b (miR-106b) is overexpressed in various types of cancers and is associated with the regulation of carcinogenic processes. However, its clinical significance in cutaneous melanoma has not been reported. qRT-PCR was performed to examine the expression of miR-106b in 15 cases of dysplastic nevi, 17 cases of melanoma metastases, and 97 cases of p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Sequencing of Gag/Env association with HIV genotyping resolution and HIV-related epidemiologic studies of HIV in China
Authors: L. Ren, H.W. Wang, Y. Xu, Y. Feng, H.F. Zhang and K.H. Wang
HIV genotyping has led to conflicting results between laboratories. Therefore, identifying the most accurate gene combinations to sequence remains a priority. Datasets of Chinese HIV subtypes based on several markers and deposited in PubMed, Metstr, CNKI, and VIP databases between 2000 and 2015 were studied. In total, 9177 cas.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048870
- DOI:
- 10.4238/gmr15048870