Biomarker
Evaluation of serum HGF and CK18 levels in patients with esophageal cancer
Authors: N. Kilic-Baygutalp, N. Ozturk, E. Orsal-Ibisoglu, B. G�¼ndogdu, F.B. Ozgeris, N. Bakan, E. Bakan and A.F. Kilic
Cytokeratins are thought to play a role in apoptosis. Cytokeratin 18 (CK18) is involved in the formation of intracellular cytoskeleton, and has been considered a promising apoptosis marker in gastrointestinal carcinomas. Growth factors, including hepatocyte growth factor (HGF), may provide a microenvironment for malignant cell.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038583
- DOI:
- 10.4238/gmr.15038583
Circulatory microRNA-145 expression is increased in cerebral ischemia
Authors: C.S. Gan, C.W. Wang and K.S. Tan
Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression .. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.27.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.27.1
Comparative proteomic analysis of ductal and lobular invasive breast carcinoma
Authors: N.C.S. Oliveira, T.H.B. Gomig, H.H. Milioli, F. Cordeiro, G.G. Costa, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027701
- DOI:
- 10.4238/gmr.15027701
Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy
Authors: X. Li, C.Y. Liu, Y.S. Li, J. Xu, D.G. Li, X.I. Li and D. Han
Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027465
- DOI:
- 10.4238/gmr.15027465
Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer
Authors: J.H. Sun, N. Fan and Y. Zhang
In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038632
- DOI:
- 10.4238/gmr.15038632
Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer
Authors: E. Aynaci, E. Coskunpinar, A. Eren, O. Kum, Y.M. Oltulu, N. Akkaya, A. Turna, I. Yaylim and P. Yildiz
Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.9
- DOI:
- 10.4238/2013.February.28.9
Genome-scale meta-analysis of DNA methylation during progression of lung adenocarcinoma
Authors: Q.H. Zhang, X.H. Dai, Z.M. Dai and Y.N. Cai
Identification of epigenetic alterations in tumors has become a common method for identifying genes critical to cancer development and progression. Thus, we identified DNA methylation alterations on the genome scale during lung adenocarcinoma (LADC) progression to understand the carcinogenic process and identify clinically relevant biomarkers. We found th.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.30
- DOI:
- 10.4238/2015.August.7.30
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course
Authors: F. Yang, J.Y. Li, Q.N. Yin, K. Yang, S.N. Dong, L.J. Bai, P. Liu and X.W. Tong
The purposes of this study were to analyze the expression and distribution of human kallikrein 5 (hK5) in triple-negative breast cancer (TNBC) tissues, to establish a standard operating procedure (SOP) for its immunohistochemical assay, and to evaluate the possibility of hK5 being a prognostic biomarker for TNBC. Recombinant hK5 protein and specific antib.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.28
- DOI:
- 10.4238/2015.August.14.28
Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer
Authors: P. Liu, F. Xin and C.F. Ma
Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy voluntee.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.25
- DOI:
- 10.4238/2015.December.22.25
Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis
Authors: M.L. Zhi, Z.J. Liu, X.Y. Yi, L.J. Zhang and Y.X. Bao
Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.28
- DOI:
- 10.4238/2015.December.22.28