Bipolar Disorder
NNT and NNT-AS1 expression levels are not different between bipolar patients and healthy subjects
Authors: Soudeh Ghafouri-Fard, Mohammad Taheri, Vahid Kholghi Oskooie, Mir Davood Omrani, Arezou Sayad
Nicotinamide nucleotide transhydrogenase (NNT) participates in redox and energy interconnections. Nnt silencing in N27 dopaminergic cells has changed basal, extra, and greatest mitochondrial oxygen absorption rates and made these cell vulnerable to constant upsurges in H2O2. NNT-antisense RNA1 (NNT-AS1) is transcribed from the opposite stand of NNT gene a.. Read More»
- Genet. Mol. Res. 18(1):
Associations of serotonin receptor gene HTR3A, HTR3B, and HTR3A haplotypes with bipolar disorder in Chinese patients
Authors: J. Jian, C. Li, J. Xu, D. Qiao, G. Mi, X. Chen and M. Tang
Single nucleotide polymorphisms (SNPs) in HTR3A and HTR3B have been reported to be associated with bipolar disorder in European and Japanese populations. We explored the roles of 21 tag SNPs in HTR3A and HTR3B in susceptibility to bipolar disorder in a Chinese cohort. Twenty-one Tag SNPs were genotyped in a study consisting of 130 patients with bipolar di.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038671
- DOI:
- 10.4238/gmr.15038671
Case study of a patient presenting both type II bipolar affective disorder and Klinefelter syndrome
Authors: H. Delavenne, J.M. Khoury, F. Thibaut and F.D. Garcia
Klinefelter syndrome (KS) is the most common sex chromosomal disorder with an estimated prevalence of 1 in 500-1000. Increased incidences of anxiety, depression, substance abuse, psychotic and behavioral disorders, and sexual disorders have been reported in patients with KS. The aim of this case study was to report a case of a.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048872
- DOI:
- 10.4238/gmr15048872
A new single-nucleotide mutation (rs362719) of the reelin (RELN) gene associated with schizophrenia in female Chinese Han
Authors: W.J. Kuang, R.F. Sun, Y.S. Zhu and S.B. Li
Reelin is an extracellular signaling protein that plays an important role in the development of the central nervous system. Post-mortem studies have shown lower reelin protein levels in the brains of patients with schizophrenia and bipolar disorder compared with controls. Genetic studies have also shown that mutations in the r.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1343
- DOI:
- 10.4238/vol10-3gmr1343