Breast Cancer
Detection of HER2 gene amplification in formalin-fixed and paraffin-embedded breast cancer tissues by quantitative real time polymerase chain reaction in ER and PR-positive HER2 immunohistochemistry 0 or ≥ 2+ breast cancer
Authors: Maisaa Al-Wohhaib*, Salah K Alwaheeb, Ghaneema Enad Al-shammari
Amplification of the human epidermal growth factor receptor 2 (HER2) genes and overexpression of its gene product, the HER2 protein was found in 20% of breast cancers. Genetic instability and hence aberrant HER2 amplification may be associated with breast cancer progression. HER2 status determination plays an important .. Read More»
- Genet. Mol. Res. 23(4):
Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer
Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali
Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039935
- DOI:
- http://dx.doi.org/10.4238/gmr16039935
MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2
Authors: T. Zhang, J.G. Wan, J.B. Liu and M. Deng
The forkhead box F2 (Foxf2) gene suppresses epithelial-mesenchymal transition via the modulation of transcription of zinc finger E-box-binding homeobox 1 (Zeb1) and epithelial (E)-cadherin, thereby inhibiting tumor metastasis. Additionally, the specific binding of microRNA (miR)-200c to Foxf2 mRNA impedes metastatic pulmonary .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038971
- DOI:
- 10.4238/gmr16038971
Cytogenetic aspects of a canine breast carcinosarcoma - a case report
Authors: C.S.D. Morais, P.R.A.M. Affonso, J.A. Bitencourt and A.A. Wenceslau
This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterati.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029433
- DOI:
- 10.4238/gmr16029433
Association of chemotactic factor receptor 5 gene with breast cancer
Authors: Y. Zhang1, F.Y. Meng2, W.L. Li1, C.X. Zhou1, Z. Guan1 and H.Y. Fan2
We designed a 2-stage study to investigate chemotactic factor receptor 5 (CCR5) gene expression in breast cancer tissues and axillary lymph nodes and analyze the association between the CCR5-Δ32 gene polymorphism and the clinical features and prognosis of breast cancer patients. The first stage examined 72 cases of invasive ductal carcinoma and axil.. Read More»
- Genet. Mol. Res. 13(3):
- 2013.November.7.4
- DOI:
- 10.4238/2013.November.7.4
Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population
Authors: W. Wei, M. Jiang, L. Luo, Z. Li, P. Wang and W.Q. Dong
Recent genome wide association studies (GWAS) and candidate gene studies have revealed many novel loci associated with colorectal cancer susceptibility. We evaluated the effect of these colorectal cancer-associated variants on the risk of breast cancer in a Chinese Han population. Seven single nucleotide polymorphisms (SNPs) (rs3856806 in PPARG, rs7014346.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.14
- DOI:
- 10.4238/2013.December.4.14
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer
Authors: J.M. He, Y.D. Pu, Y.J. Wu, R. Qin, Q.J. Zhang, Y.S. Sun, W.W. Zheng and L.P. Chen
We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vita.. Read More»
- Genet. Mol. Res. 13(4):
Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women
Authors: L. GÃ?³mez Flores-Ramos1,2, A. Escoto-De Dios1, A.M. Puebla-PÃ?©rez3, L.E. Figuera-Villanueva4, A. Ramos-Silva1,5, R. RamÃ?Ârez-PatiÃ?±o1,2, J.I. Delgado-Saucedo3, E. Salas-GonzÃ?¡lez6, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez7, A. Alonzo-Rojo1,2, I. GutiÃ?©rrez-Hurtado1,2 and M.P. Gallegos-Arreola1
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.17
- DOI:
- 10.4238/2013.November.18.17
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility
Authors: L.P. Ren, Y.S. Xian, D.M. Diao, Y. Chen, Q. Guo and C.X. Dang
BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucl.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.6
- DOI:
- 10.4238/2013.November.22.6
Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai
Authors: Y.L. Wang, X. Dai, Y.D. Li, R.X. Cheng, B. Deng, X.X. Geng and H.J. Zhang
Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have exam.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.49
- DOI:
- 10.4238/2015.November.18.49