Breast Cancer
In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells
Authors: S.J. Peng, J. Li, Y. Zhou, M. Tuo, X.X. Qin, Q. Yu, H. Cheng and Y.M. Li
Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029434
- DOI:
- 10.4238/gmr16029434
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response
Authors: L. Yang, X.W. Wang, L.P. Zhu, H.L. Wang, B. Wang, T. Wu, Q. Zhao, D.L.X.T. JinSiHan and X.Y. Wang
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorph.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038679
- DOI:
- 10.4238/gmr.15038679
A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women
Authors: F. Chen, J. Zhou, Y. Xue, S. Yang, M. Xiong, Y. Liand Q. Liu
A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We gen.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.9
- DOI:
- 10.4238/2014.January.10.9
MDR1 C3435T polymorphism in Mexican patients with breast cancer
Authors: N.M. MacÃ?Âas-GÃ?³mez, M. GutiÃ?©rrez-Angulo, E. Leal-Ugarte, L. RamÃ?Ârez-Reyes, J. Peregrina-Sandoval, J.P. Meza-Espinoza, F. Ramos Solano, M. de la Luz Ayala-Madrigal and F. Santoyo Telles
We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (Méx.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.17
- DOI:
- 10.4238/2014.July.4.17
Effect of specific silencing of EMMPRIN on the growth and cell cycle distribution of MCF-7 breast cancer cells
Authors: X.Q. Yang, J. Yang, R. Wang, S. Zhang, Q.W. Tan, Q. Lv, W.T. Meng, X.M. Mo, H.J. Li
The extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the immunoglobulin family and shows increased expression in tumor cells. We examined the effect of RNAi-mediated EMMPRIN gene silencing induced by lentiviral on the growth and cycle distribution of MCF-7 breast cancer cells. Lentiviral expressin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.24
- DOI:
- 10.4238/2015.December.1.24
Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population
Authors: R. Zhao and M.F. Ying
We conducted a case-control study to investigate the role of ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphisms in the development of breast cancer. Between March 2012 and March 2014, a total of 242 newly diagnosed breast cancer patients with histopathologically confirmed primary breast cancer and 242 healthy controls were recruited. Genotyping of ERCC1.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017263
- DOI:
- 10.4238/gmr.15017263
Gene expression profile in breast cancer comprising predictive markers for metastatic risk
Authors: S. Sirirattanakul, P. Wannakrairot, T. Tencomnao and R. Santiyanont
Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive marker.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.3
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.3
Specific BRCA1 gene variations amongst young Moroccan breast cancer patients
Authors: A. Tazzite, S. Nadiffi, D. Kottwitz, M. El Amrani, H. Jouhadi,A. Benider, A. Moumen4 and H. Sefrioui
Germline mutations in the BRCA1 gene are known predictive markers for the development of hereditary breast cancer. Nevertheless, no comprehensive study has been performed targeting the presence and relevance of BRCA1 mutations in Moroccan breast cancer patients. We here present an analysis of BRCA1 gene regions (exon 2 and exo.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.31.5
- DOI:
- http://dx.doi.org/10.4238/2014.January.31.5
Plasma human mammaglobin mRNA associated with poor outcome in patients with breast cancer
Authors: G.-W. Lee J.-Y. Kim E.-H. Koh D. Kang D.S. Choi K.-Y. Maeng J.-S. Lee
Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determin.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.28.2
- DOI:
- 10.4238/2012.November.28.2
Validation of associations between ESR1 variants and breast cancer risk in Chinese cohorts
Authors: X. Li, G.Y. Yao, F.X. Li, Y.R. Qiu and X.X. Yang
Estrogen receptor-a (ER) protein plays a key role in breast carcinogenesis, and common genetic variants in the corresponding gene locus have been associated with breast cancer risk in different populations. Here, we analyzed estrogen receptor 1 (ESR1) associations in two hospital-based studies of patients from the south of China. Three single-nucleotide p.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036683
- DOI:
- 10.4238/gmr.15036683