Breast Cancer
Germline HVR-II mitochondrial polymorphisms associated with breast cancer in Tunisian women
Authors: B. Yacoubi Loueslati, W. Troudi, L. Cherni, K.B. Rhomdhane and L. Mota-Vieira
A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr778
- DOI:
- 10.4238/vol9-3gmr778
Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer
Authors: J.-L. Zhang, Q. Yao, J.-H. Chen ,Y. Wang, H. Wang, Q. Fan, R. Ling,J. Yi and L. Wang
The objective of this study was to determine the changes in peripheral blood circulating tumor cells in HER2-positive early breast cancer before and after Herceptin therapy, and to explore the effects of the HER2 gene and Herceptin on circulating tumor cells. CK19 mRNA expression in peripheral blood was evaluated by qRT-PCR as an index of circulating tumo.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.20
- DOI:
- 10.4238/2015.March.20.20
Expression and significance of SATB1 in the development of breast cancer
Authors: S. Zhang, X. Gao, Y. Ma, J. Jiang, Z. Dai, X. Yin, W. Min, W. Hui and B. Wang
Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in di.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.10
GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
Authors: A.L. Oliveira, F.F.O. Rodrigues, R.E. Santos, T. Aoki, M.N. Rocha, C.A. Longui and M.B. Melo
The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associat.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr726
- DOI:
- 10.4238/vol9-2gmr726
Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies
Authors: Q. Wang, N.Y. Wang, X.M. Cao, X. Sun, D. Shen, M. Yuan and J.F. Chen
Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A co.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038218
- DOI:
- 10.4238/gmr.15038218
Preliminary study of the effects of �²-elemene on MCF-7/ADM breast cancer stem cells
Authors: Y. Dong, L. Li, L. Wang, T. Zhou, J.W. Liu and Y.J. Gao
We examined expression differences in breast cancer stem cells (BCSCs) of the doxorubicin-resistant breast cancer cell line MCF-7/ADM and doxorubicin-sensitive cell line MCF-7/S. The effects of Chinese medicine β-elemene on BCSCs and resistance protein expression were determined. The serum-free cell culture method was used for cell culture, and morph.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.20
- DOI:
- 10.4238/2015.March.27.20
Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women
Authors: J. Shi, L.H. Li, X.Y. Duan, Q. Liu, L.L. Sun and Y.T. Tian
Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymor.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038332
- DOI:
- 10.4238/gmr.15038332
Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China
Authors: M.-Y. Sun X.-X. Yang W.-W. Xu G.-Y. Yao H.-Z. Pan M. Li
Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations o.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.26.1
- DOI:
- 10.4238/2012.September.26.1
Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population
Authors: Q. Pan Y. Ning L.Z. Chen S. Zhang Z.Z. Liu X.X. Yang W. Wei H. Wei Q.G. Li H.N. Yue J.X. Wang
Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.17.1
- DOI:
- 10.4238/2012.September.17.1
Genes up- and down-regulated by dermcidin in breast cancer: a microarray analysis
Authors: D.F. Moreira, B.E. Strauss, E. Vannier and J.E. Beliz�¡rio
3-fold change and p 0.005). The gene expression of 208 was reduced and of 27 was increased in the three DCD-RNAi clones compared to pLKO control clone. The expression of 77 genes (37%) encoding for enzymes involved in amino acid metabolism, glucose metabolism and oxidoreductase activity and several genes required for cell surv.. Read More»
- Genet. Mol. Res. 7(3):
- vol7-3x-meeting009
- DOI:
- 10.4238/vol7-3x-meeting009