Breast Cancer
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil
Authors: Rozany Mucha Dufloth, Sandra Costa, Fernando Schmitt and Luiz Carlos Zeferino
Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an.. Read More»
- Genet. Mol. Res. 4(4):
Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer
Authors: J. Li, Z.J. Song, Y.Y. Wang, Y. Yin, Y. Liu and X. Nan
MicroRNA (miRNA) deregulation has been previously linked to the initiation and development of breast cancer. Although miR-99a is aberrantly expressed in many types of cancers, including breast cancer, the serum miR-99a expression level in breast cancer and its clinical significance remains unknown. Blood samples were obtained from 72 patients with breast .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038338
- DOI:
- 10.4238/gmr.15038338
PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells
Authors: C.-G. Sun, J. Zhuang, W.-J. Teng, Z. Wang and S.-S. Du
We explored whether p53 upregulated modulator of apoptosis (PUMA) gene transfection could enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells. The liposome-mediated recombinant eukaryotic expression vector PUMA-pCDNA3 and empty vector plasmid were stably transfected into MCF-7 cells. Epirubicin (0.01-100 μM) was applied.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.6
- DOI:
- 10.4238/2015.May.29.6
Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression
Authors: G.-F. Li, T.-L. Qian, G.-S. Li, C.-X. Yang, M. Qin, J. Huang, M. Sun and Y.-Q. Han
Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproa.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.13.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.13.1
Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in women with locally advanced breast cancer
Authors: F.F.O. Rodrigues, R.E. Santos, M.B. Melo, M.A.L.G. Silva, A.L. Oliveira, R.L. Rozenowicz, L.B. Ulson and T. Aoki
Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associat.. Read More»
- Genet. Mol. Res. 7(1):
CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women
Authors: L. Yang, X.Y. Wang, Y.T. Li, H.L. Wang, T. Wu, B. Wang, Q. Zhao, D. Jinsihan and L.P. Zhu
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment length.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.15
- DOI:
- 10.4238/2015.July.28.15
Adjuvant chemotherapy may improve survival of patients with luminal A breast cancer and positive lymph nodes
Authors: Y. Han, Q. Li, B.H. Xu, P. Zhang, P. Yuan, J.Y. Wang, F. Ma, R.G. Cai and Y. Fan
The study examined the clinicopathological characteristics and treatment options in patients with luminal A breast cancer. This retrospective cohort included 1580 patients with luminal A breast cancer treated between January 2005 and June 2007. Patients were divided into four subgroups according to lymph node status. Prognostic factors and 5-year overall .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.4
- DOI:
- 10.4238/2015.July.31.4
Genetic variation in ERCC1 and XPF genes and breast cancer risk
Authors: X.H. Pei, Z. Yang, X.Q. Lv, and H.X. Li,
Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were g.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.6
- DOI:
- 10.4238/2014.March.31.6
Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer
Authors: D.S. Vasconcelos, F.P.E. da Silva, L.G. Quintana, N.P. Anselmo, M.A.K. Othman, T. Liehr and E.H.C. de Oliveira
Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor ge.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.15
- DOI:
- 10.4238/2013.January.4.15
Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer
Authors: X. Tan, Y.Y. Wang, X.Y. Chen, L. Xian, J.J. Guo1, G.B. Liang and M.W. Chen
The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-a.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.10
- DOI:
- 10.4238/2014.September.12.10