Breast Cancer
Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population
Authors: P. Qi, L. Wang, B. Zhou, W.J. Yao, S. Xu, Y. Zhou and Z.B. Xie
Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide poly.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.2
- DOI:
- 10.4238/2015.June.11.2
Comparative proteomic analysis of ductal and lobular invasive breast carcinoma
Authors: N.C.S. Oliveira, T.H.B. Gomig, H.H. Milioli, F. Cordeiro, G.G. Costa, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027701
- DOI:
- 10.4238/gmr.15027701
Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis
Authors: N. Wang, P. Chen, L.P. Huang and T.Z. Wang
Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027350
- DOI:
- 10.4238/gmr.15027350
Mammaglobin and maspin transcripts in blood may reflect disease progression and the effect of therapy in breast cancer
Authors: O. Bitisik, P. Saip, S. Saglam, D. Derin and N. Dalay
Detection of residual tumor cells in the circulation can provide prognostic as well as therapeutic information and help in identifying patients at high risk for developing metastases. Maspin and mammaglobin are two molecules that are specifically associated with breast cancer. We looked for mammaglobin and maspin transcripts i.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr649
- DOI:
- 10.4238/vol9-1gmr649
Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients
Authors: M. Taheri, F. Mahjoubi and R. Omranipour
One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports ma.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr669
- DOI:
- 10.4238/vol9-1gmr669
TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis
Authors: X.P. Lu, G.N. Hu, J.Q. Du and H.Q. Li
Numerous studies have evaluated the association between TCF7L2 gene polymorphisms (rs12255372 and rs7903146) and breast cancer risk. However, the results have been inconsistent. Therefore, in the current study, we performed a meta-analysis. A systematically literature search of the PubMed and EMBASE databases was conducted in November 2013, and the refere.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.16
- DOI:
- 10.4238/2015.March.31.16
Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer
Authors: J.H. Sun, N. Fan and Y. Zhang
In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038632
- DOI:
- 10.4238/gmr.15038632
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico
Authors: G. Jaramillo-Rangel, M. Ortega-MartÃ?Ânez, R.M. Cerda-Flores andH.A. Barrera-SaldaÃ?±a
Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The pur.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.22
- DOI:
- 10.4238/2015.June.11.22
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development
Authors: T. Zara-Lopes, A.P.A. Gimenez-Martins, C.H.V. Nascimento-Filho, M.M.U. Castanhole-Nunes, A.L.S. Galbiatti-Dias, J.A. Padovani-J�ºnior, J.V. Maniglia, J.L.E. Francisco, E.C. Pavarino and E.M. Goloni-Bertollo
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MT.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028222
- DOI:
- 10.4238/gmr.15028222