Breast Cancer
Expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 in breast cancer
Authors: L. Zhang, W.P. Yang, L.Y. Wu, X. Zhu and C.Y. Wei
Our objective was to explore the expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 (Keap1) in breast cancer tissue. Eighty-one breast cancer patients having undergone surgical treatment in our hospital between March 2002 and December 2008 were enrolled in this study. Normal tissue adjacent.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027294
- DOI:
- 10.4238/gmr.15027294
Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis
Authors: Y. Zhang, Y.F. Yu, J.Z. Wang and H. Jia
This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and scree.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.14
- DOI:
- 10.4238/2015.August.3.14
Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women
Authors: Z. Pan, Z. Fu, Q. Song, W. Cao, W. Cheng and X. Xu
Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028640
- DOI:
- 10.4238/gmr.15028640
Associations between the SRD5A2 gene V89L and TA repeat polymorphisms and breast cancer risk: a meta-analysis
Authors: D. Zhang, Q. Li, H.-C. Qu, T. Yu and Y.-R. Liu
The 5α-reductase type 2 (SRD5A2) gene plays a significant role in the development of breast cancer. The V89L and TA repeat polymorphisms of the SRD5A2 gene have been considered as risk factors for breast cancer. However, the results have been inconsistent. To resolve this conflict, we performed a meta-analysis of studies with V89L (1144 patients and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.9
- DOI:
- 10.4238/2015.August.7.9
S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation
Authors: Y.J. Sun, X.K. Wang and B.J. Li
We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.4
- DOI:
- 10.4238/2015.August.10.4
Value of diffusion weighted imaging in the differential diagnosis of benign and malignant breast lesions at 3.0T MRI
Authors: X.Y. Jiang, Q.Z. Xie, X.S. Cao, T. Gao, C.Y. Xing and X.L. Li
The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent br.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.15
- DOI:
- 10.4238/2014.September.26.15
Tristetraprolin: a novel mediator of the anticancer properties of resveratrol
Authors: C. Li, C. Tang and G. He
Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027213
- DOI:
- 10.4238/gmr.15027213
Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis
Authors: P. Yuan, L. Yuan, B.L. Xu, C.Z. Wang, H.Z. Yang and Y. Li
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.15
- DOI:
- 10.4238/2015.December.11.15
Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis
Authors: J.L. Huan, X. Gao, L. Xing, X.J. Qin, H.X. Qian, Q. Zhou and L. Zhu
The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.5
- DOI:
- 10.4238/2014.September.29.5
Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer
Authors: X. Huang, Y. Yang, Y. Guo, Z.L. Cao, Z.W. Cui, T.C. Hu and L.B. Gao
Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.19
- DOI:
- 10.4238/2015.December.14.19