Breast Cancer
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
Authors: A. Ramos-Silva,L.E. Figuera,O.M. Soto-Quintana,A.M. Puebla-PÃ?©rez,R. RamÃ?Ârez-PatiÃ?±o,I. GutiÃ?©rrez-Hurtado,D.I. Carrillo-Moreno, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez,I.P. DÃ?¡valos-RodrÃ?Âguez and M.P. Gallegos-Arreola
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and t.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.16
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Authors: S.H. Ma, F.H. Ling, Y.X. Sun, S.F. Chen and Z. Li
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028066
- DOI:
- 10.4238/gmr.15028066
Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer
Authors: Y. Yu, F. Lv, H. Lin, G. Qian, Y.S. Jiang, L.X. Pang, Y.P. Wang, X.F. Wang, Y.M. Kang, C.B. Li, Q. Liu, J.Z. Xu and W. You
Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.12
- DOI:
- 10.4238/2015.December.21.12
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course
Authors: F. Yang, J.Y. Li, Q.N. Yin, K. Yang, S.N. Dong, L.J. Bai, P. Liu and X.W. Tong
The purposes of this study were to analyze the expression and distribution of human kallikrein 5 (hK5) in triple-negative breast cancer (TNBC) tissues, to establish a standard operating procedure (SOP) for its immunohistochemical assay, and to evaluate the possibility of hK5 being a prognostic biomarker for TNBC. Recombinant hK5 protein and specific antib.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.28
- DOI:
- 10.4238/2015.August.14.28
Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis
Authors: M. Kuang, W. Xu, C.X. Cao, L.L. Shen, J. Chang, X.L. Zhang, J.F. Chen and C.J. Tang
Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this me.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027771
- DOI:
- 10.4238/gmr.15027771
Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression
Authors: H. He, J. Chen, W.P. Xie, S. Cao, H.Y. Hu, L.Q. Yang and B. Gong
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes br.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.7
- DOI:
- 10.4238/2013.January.4.7
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2
miR-125a-5p expression is associated with the age of breast cancer patients
Authors: H. He, F. Xu, W. Huang, S.Y. Luo, Y.T. Lin, G.H. Zhang, Q. Du and R.H. Duan
Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.17
- DOI:
- 10.4238/2015.December.22.17
Effect of lipoic acid combined with paclitaxel on breast cancer cells
Authors: B.J. Li, X.Y. Hao, G.H. Ren and Y. Gong
Breast cancer is the most common gynecologic tumor globally that threatens women’s health. Lipoic acid is a type of antioxidant that can alleviate oxidative stress damage. Studies showed that lipoic acid could inhibit the proliferation of tumor cells in cervical cancer and colon cancer. This paper intends to explore the combined effect of lipoic aci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.18
- DOI:
- 10.4238/2015.December.22.18
Protein-protein interaction between ezrin and p65 in human breast cancer cells
Authors: R. Tang, F.X. Li, W.F. Shao, Q.S. Wen, X.R. Yu and J.B. Xiong
Our study aimed to investigate the co-localization and protein-protein interactions between ezrin and p65 in human breast cancer cells. Liquid chromatography-mass spectrometry (LCMS) was used to uncover novel protein interactions with ezrin in MDA-MB-231 cells. Endogenous co-immunoprecipitation was used to validate protein-pro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028334
- DOI:
- 10.4238/gmr.15028334