Cancer
Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis
Authors: Y. Zhao, J.G. Qi, N. Yang, Y.L. Lin, J. Liang and X. Zhu
A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-co.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.39
- DOI:
- 10.4238/2015.November.18.39
Association analysis of IL-17A and IL-17F polymorphisms in Chinese women with cervical cancer
Authors: L. Li, Y.L. Tian, X.M. Lv, H.F. Yu, Y.Y. Xie, J.D. Wang and W. Shi
We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs22.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.6
- DOI:
- 10.4238/2015.October.9.6
DNA sequence variants in the carbonyl reductase 1 (cbr1) gene in seven breeds of Canis lupus familiaris
Authors: Q. Cheng, C. Sanborn, D. Ferguson and J.G. Blanco
The anticancer anthracyclines doxorubicin and daunorubicin are used to treat a variety of cancers in dogs. The therapeutic utility of anthracyclines is limited by cardiotoxicity in some cases. Synthesis of anthracycline alcohol metabolites by carbonyl reductase 1 (CBR1) is crucial for the pathogenesis of cardiotoxicity. We hyp.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.10
- DOI:
- 10.4238/2012.April.27.10
ZNF797 plays an oncogenic role in gastric cancer
Authors: D. Momenzadeh1, S. Rahman Zadeh1, M. Rezaei-Tavirani1, A. Baradaran-Rafii2, F. Ghasemvand1 and S. Heidari-Keshel1
Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, selfrenewal. A complex network of transcription factors and signaling molecules are required for continuation of this trait. ZNF797 (SALL4) is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; howe.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.18
- DOI:
- 10.4238/2014.October.20.18
Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations
Authors: L. Xu, J. Lei, Q.Z. Wang, J. Li and L. Wu
Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics in genotype-specific subsets of patients w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.18
- DOI:
- 10.4238/2015.October.21.18
Combination of multiple gene markers to detect circulating tumor cells in the peripheral blood of patients with non-small cell lung cancer using real-time PCR
Authors: M. Ding, X. Li and T. Qiu
Our study aims to determine the clinical significance of human telomerase reverse transcriptase (hTERT), S-phase kinase-associated protein 2 (Skp2) and thyroid transcription factor-1 (TTF-1) mRNA expressions in peripheral blood (PB) of patients with non-small cell lung cancer (NSCLC). Real-time polymerase chain reaction was used to investigate the gene ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.24
- DOI:
- 10.4238/2015.October.21.24
Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro
Authors: M. Yue, X.J. Shen, Y.X. Liu, X.Y. Lin, S.Q. Zhou and Y.H. Song
Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We inve.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.12
- DOI:
- 10.4238/2015.November.30.12
Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer
Authors: J. Li, X.F. Jia, J. Liu, J.J. Liu and H.B. Zhao
The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.5
- DOI:
- 10.4238/2015.October.5.5
729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer
Authors: B. Wan, J. Tan, Q. Zeng, L.Y. He, Y. Gan, Y.B. Dai and K. Yao
In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 20.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.26
- DOI:
- 10.4238/2015.November.30.26
RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer
Authors: S. SuÃ?¡rez-Villanueva, M.L. Ayala-Madrigal, J. Peregrina-Sandoval, N. MacÃ?Âas-GÃ?³mez, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz-Mendoza, J.M. Moreno-Ortiz, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, E. Cabrales and M. GutiÃ?©rrez-Angulo
We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected b.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.28
- DOI:
- 10.4238/2015.November.30.28