Cancer
Association of the GSTM1 null polymorphism with breast cancer in a Mexican population
Authors: O. Soto-Quintana, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez, R. RamÃ?Ârez-PatiÃ?±o, A. Ramos-Silva, L.E. Figuera, D.I. Carrillo-Moreno, I.A. GutiÃ?©rrez-Hurtado, A.M. Puebla-PÃ?©rez, B. SÃ?¡nchez-Llamas and M.P. Gallegos-Arreola
The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion inthe mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotyp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.2
- DOI:
- 10.4238/2015.October.26.2
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China
Authors: S.Y. Yang, D. Aisimutula, H.F. Li, Y. Hu, X. Du, J. Li and M.X. Luan
Mutations in the BRCA1/2 genes are associated with an increased risk of breast cancer, but no large-scale research have examined the BRCA1/2 mutations in Chinese Kazakh women. We evaluated the frequency and distributions of BRCA1 and BRCA2 gene mutations in Kazakh sporadic breast cancer patients and healthy women in China. The association between the clin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.11
- DOI:
- 10.4238/2015.October.26.11
Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis
Authors: Y. Du, L. Gao , K. Zhang and J. Wang
The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.20
- DOI:
- 10.4238/2015.October.26.20
Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer
Authors: W.T. Qi, J.L. Gao and S.S. Zhang
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.33
- DOI:
- 10.4238/2015.October.26.33
MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell
Authors: Q.S. Anders, E. Stur, L.P. Agostini, F.M. Garcia, R.S. Reis, J.A. Santos, S.O. Mendes, L.L. Maia, G.T. Peterle, V. Stange, M.B. Carvalho, E.H. Tajara, M. Santos, A.M.A. Silva-Conforti and I.D. Louro
The C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous ce.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.6
- DOI:
- 10.4238/2015.October.26.6
Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2
Authors: X.M. Tian, Y.Z. Luo, P. He, J. Li, Z.W. Ma and Y. An
Prostate cancer is a common malignancy of the male reproductive-urinary system. MDM2 is an oncogene, whose expression can be regulated by microRNA (miRNA). The present study investigated the expression and correlation of miRNA-509-5p and MDM2 to determine the mechanism of their function in invasion and migration of prostate ca.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019195
- DOI:
- 10.4238/gmr16019195
MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5
Authors: T.K. Li, K. Yin, Z. Chen, Y. Bao and S.X. Zhang
Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bio.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019327
- DOI:
- 10.4238/gmr16019327
Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer
Authors: Y. Shen, Y.F. Ye, L.W. Ruan, L. Bao, M.W. Wu and Y. Zhou
Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019479
- DOI:
- 10.4238/gmr16019479
Genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene in Chinese patients with gastric cancer
Authors: J. Liu X. Li N. Yu Y.-Q. Yang X. Li Z.-Y. Ye J.-C. Li
We explored a possible correlation of genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene with clinicopathologic features of gastric cancer in Chinese patients and looked for molecular markers for diagnosing gastric tumor development. Microsatellite instability and loss of heterozygosity of the PAI-1 gene locus D7S515, D7S471 .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.11
- DOI:
- 10.4238/2012.May.18.11
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells
Authors: L. Zhang, H.E.X.D. Niyazi, H.R. Zhao, X.P. Cao, M.N.S. Abudula, W.J. Ye, S.A. Zhang, R.H.M. Yiming, Y. Zhang, W.P. Su, R. Chen, Y. Ouyang, N. Miao and Y.X. Bao
Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyze.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019269
- DOI:
- 10.4238/gmr16019269