Cancer
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review
Authors: P.H.S. Klinger, A.F. Andrade, L.E.A. Delsin, R.G.P. Queiroz, C.A. Scrideli, L.G. Tone and E.T. Valera
Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigene.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019412
- DOI:
- 10.4238/gmr16019412
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes
Authors: J. Zekri, A. Al-Shehri, M. Mahrous, S. Al-Rehaily, T. Darwish, S. Bassi, H. El Taani, A. Al Zahrani, S. Elsamany, J. Al-Maghrabi and B.B. Sadiq
Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019369
- DOI:
- 10.4238/gmr16019369
Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer
Authors: D.H. Xiu, Y. Chen, L. Liu, H.S. Yang and G.F. Liu
Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC t.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019272
- DOI:
- 10.4238/gmr16019272
Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors
Authors: A.-X. Wang B. Xu N. Tong S.-Q. Chen Y. Yang X.-W. Zhang H. Jiang N. Liu J. Liu X.-N. Hu G.-Z. Sha M. Chen
Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the pre-miR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking stat.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.2
- DOI:
- 10.4238/2012.August.31.2
Dynamic relationship between SIPA1 gene and protein expression and the development of gastric cancer
Authors: J.Y. Li, J.B. Wang, C.B. Liu, D.L. Ma, J.H. Ma
Association of signal-induced proliferation-associated 1 (SIPA) gene and protein expression with gastric cancer development was examined. SIPA1 mRNA and protein levels were determined by real-time quantitative polymerase chain reaction and western blot, respectively, in 40 gastric tumor and tumor-adjacent normal tissues. SIPA1.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019271
- DOI:
- 10.4238/gmr16019271
CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer
Authors: T.D. Silva A.V. Felipe C.A.M. Pimenta K. Bar�£o N.M. Forones
We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age to 206 healthy controls. The mean age of the two groups was 62 years. Meat intake, cigarette smoking a.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.2
- DOI:
- 10.4238/2012.September.3.2
Role of interleukin-6 gene polymorphisms in the development of prostate cancer
Authors: C.H. Chen, M. Gong, Q.T. Yi and J.H. Guo
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. A total of 212 consecutive primary prostate cancer patients and 236 control subjects were recruited between May 2012 and May 2014. The IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796) polymorp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.34
- DOI:
- 10.4238/2015.October.26.34
Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk
Authors: Y.M. Zhang X.C. Zhou Z. Xu C.J. Tang
In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.25.7
- DOI:
- 10.4238/2012.September.25.7
Lack of association between the cyclooxygenase 2 -765G>C polymorphism and prostate cancer risk: a meta-analysis
Authors: Y.-Q. Feng, Y.U. Li, W.-D. Xiao, G.-X. Wang and Y.O. Li
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis. A systematic literature search was performed using the PubMed, Embase, Cochrane Library, and Google Scholar databases by using the terms “cyclooxygenase-2/COX-2/PTGs2”.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.1
- DOI:
- 10.4238/2015.October.28.1
Correlation between expression and significance of �´-catenin, CD31, and VEGF of non-small cell lung cancer
Authors: X.L. Liu, L.D. Liu, S.G. Zhang, S.D. Dai, W.Y. Li and L. Zhang
We analyzed the expression and clinical significance of δ-catenin in non-small cell lung cancer (NSCLC) and investigated prognosis using human lung cancer samples. Eighty-nine NSCLC patients underwent operation between January and March 2009. There were 53 cases of squamous cell carcinoma, 31 adenocarcinoma, and 5 large cell carcinoma. δ-Caten.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.10
- DOI:
- 10.4238/2015.October.28.10