Cancer
Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk
Authors: D.Y. Zhong H.Y. Chu M.L. Wang L. Ma D.N. Shi Z.D. Zhang
The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studi.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.4
- DOI:
- 10.4238/2012.September.26.4
Expression of PCA3 and PSA genes as a biomarker for differential diagnosis of nodular hyperplasia and prostate cancer
Authors: F. Fonseca Coelho, F. Loli Guimar�£es, W.L. Ribeiro Cabral, P.G. Oliveira Salles, E. Cueva Mateo, L. Mendes Nogueira e Nogueira, C.E. Corradi Fonseca and K. Braga Gomes
We evaluated the expression of the PCA3 gene in urine from patients with nodular hyperplasia/benign prostatic hyperplasia (PNH) or adenocarcinoma type prostate cancer (PCa).The study included 59 men: 22 with PCa, 26 with PNH, and 11 with no alterations (controls). Patients’ urine was collected following prostatic massage and quantified by quantitati.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.13
- DOI:
- 10.4238/2015.October.28.13
Bioinformatics analysis with graph-based clustering to detect gastric cancer-related pathways
Authors: P. Liu X. Wang C.H. Hu T.H. Hu
Despite a dramatic reduction in incidence and mortality rates, gastric cancer still remains one of the most common malignant tumors worldwide, especially in China. We sought to identify a set of discriminating genes that could be used for characterization and prediction of response to gastric cancer. Using bioinformatics analysis, two gastric cancer datas.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.5
- DOI:
- 10.4238/2012.September.26.5
Implicating the H63D polymorphism in the HFE gene in increased incidence of solid cancers: a meta-analysis
Authors: L.L. Shen, D.Y. Gu, T.T. Zhao, C.J. Tang, Y. Xu and J.F. Chen
A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors. However, the clinical outcomes were inconsistent. Therefore, this meta-analysis was conducted.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.36
- DOI:
- 10.4238/2015.October.28.36
The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population
Authors: H. Wang Y. Zhao J. Ma G. Zhang Y. Mu G. Qi Z. Fang L. Wang Q. Fan Z. Ma
Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms pr.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.22.5
- DOI:
- 10.4238/2013.January.22.5
Relationship between CYP17 gene polymorphisms and risk of prostate cancer
Authors: J. Song, Z.-H. Tao, X.-Y. Liu, S. Gong and L. Gan
Cytochrome P450 17a-hydroxylase (CYP17) plays a critical role in androgen biosynthesis. Polymorphisms of the CYP17 promoter have been proposed as risk factors for prostate cancer; however, some studies have produced inconclusive or controversial results. We investigated the relationship between polymorphisms of the CYP17 gene and the risk of prostate canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017866
- DOI:
- 10.4238/gmr.15017866
Association analysis of rs2275913G>A and rs763780T>C interleukin 17 polymorphisms in Chinese women with cervical cancer
Authors: L.X. Sun, X.B. Wang and X.J. Huang
We conducted a case-control study with a relatively large sample size, and investigated the association between rs2275913G>A and rs763780T>C and the risk of cervical cancer. Three hundred and six newly diagnosed patients with histologically confirmed cervical cancer and 354 cancer-free control subjects were recruited from the Forestry General Hospit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.22
- DOI:
- 10.4238/2015.October.28.22
5-Aza-2�-deoxycytidine may influence the proliferation and apoptosis of cervical cancer cells via demethylation in a dose- and time-dependent manner
Authors: T.T. Yao S.M. Mo L.Y. Liu H.W. Lu M.L. Huang Z.Q. Lin
The methylation of tumor suppressor genes has been shown to be involved in many human cancers. 5-Aza-2’-deoxycytidine (5-Aza-CdR) can reactivate the expression of methylated tumor suppressor genes. In our study, 2 human cervical cancer cell lines, HeLa and SiHa, were treated with different concentrations (20, 10, 5, and 2.5 μM) of 5-Aza-CdR for 2.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.4.5
- DOI:
- 10.4238/2013.February.4.5
Somatic copy-neutral loss of heterozygosity and copy number abnormalities in Malaysian sporadic colorectal carcinoma patients
Authors: Y.Y. Yam B.P. Hoh N.H. Othman S. Hassan M.M. Yahya Z. Zakaria R. Ankathil
Colorectal cancer is one of the most common cancers in many countries, including Malaysia. The accumulation of genomic alterations is an important feature of colorectal carcinogenesis. A better understanding of the molecular events underlying the stages of colorectal carcinogenesis might be helpful in the detection and management of the disease. We used a.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.7.1
- DOI:
- 10.4238/2013.February.7.1
Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals’ susceptibility to cancers. We aimed to investigate the asso.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018877
- DOI:
- 10.4238/gmr16018877