Cancer
Differential expression of hENT1 and hENT2 in colon cancer cell lines
Authors: Y. Liu, T. Zuo, X. Zhu, N. Ahuja and T. Fu
Human equilibrative nucleoside transporters (hENT) 1 and 2, encoded by SLC29A1 and SLC29A2, permit the bidirectional passage of nucleoside analogues into cells and may correlate with clinical responses to chemotherapy in patients with colorectal cancer (CRC). The purpose of this study was to evaluate the expression profiles of.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019549
- DOI:
- 10.4238/gmr16019549
5-Fluorouracil induces apoptosis of colorectal cancer cells
Authors: J.T. Zhang1, W.L. Zhou2, C. He3, T. Liu1, C.Y. Li1 and L. Wang1
5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017326
- DOI:
- 10.4238/gmr.15017326
Vasculogenic mimicry and hypoxia-inducible factor-1�± expression in cervical squamous cell carcinoma
Authors: T.J. Zhou1, X.H. Huang1, L. Gong1 and L. Xiang2
In this study, the existence of vasculogenic mimicry (VM) in cervical squamous cell carcinoma was investigated. To this end, the relationship between hypoxia-inducible factor 1α (HIF-1α) and the development, infiltration, and metastasis of cervical squamous cell carcinoma was studied. Between January 2010 and December 2010, 67 human cervical s.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017396
- DOI:
- 10.4238/gmr.15017396
Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target
Authors: H.-B. Zhao, X.-F. Zhang, H.-B. Wang and M.-Z. Zhang
Migration and invasion enhancer 1 (MIEN1) is a membrane-anchored protein that is highly expressed in various types of cancer, and is correlated with the PI3K/AKT pathway. The aim of this study was to investigate the expression of MIEN1 and its clinical pathological significance in breast cancer. We used immunohistochemical sta.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019380
- DOI:
- 10.4238/gmr16019380
Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas
Authors: P.K. Mishra, S.K. Jatawa, G.V. Raghuram, N. Pathak, A. Jain,A. Tiwari, S. Varshney and K.K. Maudar
Gallbladder carcinoma is an uncommon, but highly malignant tumor, with poor prognostic, and diagnostic manifestations in early stages. The Indian Council of Medical Research reported increased incidence of gallbladder carcinoma in the surviving population of the Bhopal gas tragedy that involved exposure of more than 500,000 pe.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr653
- DOI:
- 10.4238/vol8-4gmr653
Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis
Authors: J.Y. Ban, J.I. Shin and C.-H. Oh
The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.11
- DOI:
- 10.4238/2015.October.29.11
Nested polymerase chain reaction technique for the detection of Gpc3 and Afp mRNA in liver cancer micrometastases
Authors: J. Luo, K. Yang and Y.G. Wen
The incidence of liver cancer has gradually risen to a high level in China, and tumor metastasis occurs via multiple pathways. Alpha fetal protein (AFP) is the main biomarker of liver cancer micrometastases. A recent study showed that glypican-3 (GPC3), which is abundant in hepatoma cells, has promising specificity and could b.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018947
- DOI:
- 10.4238/gmr16018947
Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report
Authors: M.S. Brassesco, E.T. Valera, A.M. Castro-Gamero, D.A. Moreno,T.P. Silveira, B.M. Mori, E.E. Engel4, C.A. Scrideli and L.G. Tone
Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown histogenesis showing predominantly epithelioid cytomorphology. We conducted a conventional and molecular cytogenetic study of a 27-year-old male with epithelioid sarcoma with angiomatoid features. Cytogenetic analysis of epithelioid sarcoma metaphase spread.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr656
- DOI:
- 10.4238/vol8-4gmr656
Evaluation of the effects of androgen receptor gene trinucleotide repeats and prostate-specific antigen gene polymorphisms on prostate cancer
Authors: D. Alptekin, M. Izmirli, Y. Bayazit, H.U. Luleyap, M.B. Yilmaz, B. Soyupak, M.A. Erkoc and Z. Tansug
The number of trinucleotide repeats [CAG (coding for polyglutamine), GGC (coding for polyglycine)] in the first exon of the androgen receptor (AR) gene and prostate-specific antigen (PSA) gene androgen response element I A/G polymorphism are both related to prostate cancer prognosis. We investigated whether these genomic chang.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.1
- DOI:
- 10.4238/2012.May.18.1
A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population
Authors: Q. Ren, B. Xu, S.Q. Chen, Y. Yang, C.Y. Wang, Y.D. Wang, X.H. Wang, L.X. Hua and M. Chen
Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.5
- DOI:
- 10.4238/2012.May.15.5