Cancer
Meta-analysis of TP73 polymorphism and cervical cancer
Authors: H. Feng, L. Sui, M. Du and Q. Wang
The aim of this study was to investigate the tumor protein p73 (TP73) G4C14-A4T14 polymorphism and to perform a meta-analysis to assess TP73 expression in cervical cancer and precancerous tissue. Articles containing data regarding TP73 status in cervical cancer patients and healthy controls were retrieved from PubMed, EMBASE, .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16016571
- DOI:
- 10.4238/gmr16016571
XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people
Authors: X. Wang, K.W. Ma, Y.G. Zhao, G.J. Wang, W. Li
Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nucleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.3
- DOI:
- 10.4238/2015.December.1.3
Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells
Authors: F.J. Ji, X.F. Tian, X.W. Liu, L.B. Fu, Y.Y. Wu, X.D. Fang,H.Y. Jin
The aim of the present study was to determine the antiproliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), la.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.7
- DOI:
- 10.4238/2015.December.1.7
Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking
Authors: T.M. Silva, C.R. Marques, M.F. Marques Filho, A.B. Marques, G. Di Pietro and F. Rios-Santos
Polymorphisms in genes encoding xenobiotic-metaboli- zing enzymes might explain differences in the susceptibility to upper aerodigestive tract (UADT) cancers in individuals exposed to tobacco or other carcinogens. The present study aimed to evaluate the association of polymorphisms in the glutathione S-transferase (GST) candid.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.21.22
- DOI:
- http://dx.doi.org/10.4238/2014.January.21.22
Genetic variability of XRCC1 influences the treatment outcome of gastric cancer
Authors: H.Q. Hu1, F. Wang2, X. Du2, X.Z. Zhao2, Z. Jin2 and M.X. Hou2
We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017452
- DOI:
- 10.4238/gmr.15017452
Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer
Authors: M.A. Rosales-Reynoso, L.I. Wence-Chavez, A.R. Arredondo-Valdez,S. Dumois-Petersen, P. Barros-NÃ?ºÃ?±ez, M.P. Gallegos-Arreola, S.E. Flores-MartÃ?Ânez and J. SÃ?¡nchez-Corona
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metab.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019324
- DOI:
- 10.4238/gmr16019324
Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis
Authors: Y. Liu, X.L. Song, G.L. Zhang, A.M. Peng, P.F. Fu, P. Li, M. Tan, X. Li, M. Li and C.H. Wang
The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, mult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.19
- DOI:
- 10.4238/2015.January.15.19
HPV31 and HPV33 incidence in cervical samples from women in Recife, Brazil
Authors: M.F.P.T. Baldez da Silva, B.S. Chagas, V. Guimar�£es, L.M.C. Katz,P.M. Felix, P.M. Miranda, A.A. Lima, L.C. Arraes, D.B.G. Martins, J.L. Lima Filho, R.C. Stocco, S. Crovella,7, A.C. Freitas and W. Be�§ak
Human papillomavirus (HPV) has been extensively studied concerning genomic structure, infection mechanisms, and diversity of types, as well as disease progression stages and development of vaccines. HPV type prevalence can differ in specific populations in different countries, according to ethnicity. This is the first report o.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr677
- DOI:
- 10.4238/vol8-4gmr677
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells
Authors: H. Yan, J.Y. Xia and F.Z. Feng
The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019411
- DOI:
- 10.4238/gmr16019411
miR-187 induces apoptosis of SiHa cervical carcinoma cells by downregulating Bcl-2
Authors: C.Y. He and J. Yang
Cervical carcinoma is a life-threatening illness posing considerable danger to women’s health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018969
- DOI:
- 10.4238/gmr16018969