Cancer
Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer
Authors: B.C. Almeida1, J.P.F.O. Kleine1, C.M. Camargo-Kosugi1,2, M.R. Lisboa1,C.N. Fran�§a3, J.P. Fran�§a4 and I.D.C.G. Silva1
The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017055
- DOI:
- 10.4238/gmr.15017055
Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population
Authors: R. RamÃ?Ârez-RamÃ?Ârez, M. GutiÃ?©rrez-Angulo, M.T. MagaÃ?±a, J.M. Moreno-Ortiz, M. Partida-PÃ?©rez, R. MuÃ?±iz-Mendoza, J. Peregrina-Sandoval, A.S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V.M. Maciel-GutiÃ?©rrez, E. Cabrales-Vazquez and M.L. Ayala-Madrigal
The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed t.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.9
- DOI:
- 10.4238/2015.January.23.9
Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population
Authors: J.M. Liu J.N. Liu M.T. Wei Y.Z. He Y. Zhou X.B. Song B.W. Ying J. Huang
Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs194651.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.15.2
- DOI:
- 10.4238/2013.March.15.2
Combined detection of p53, p16, Rb, and EGFR mutations in lung cancer by suspension microarray
Authors: Y. Ye, D. Wang, C. Su, T. Rong and A. Guo
Mutations of some contributing factors (p53, p16, Rb, and EGFR) are believed to affect diagnosis and drug resistance of lung cancer. We evaluated the efficacy of a multimarker panel for molecular diagnosis of lung cancer, using a high-throughput suspension microarray. One hundred and twenty-five lung cancer specimens and 30 tu.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr627
- DOI:
- 10.4238/vol8-4gmr627
Influence of suppression of CapG gene expression by siRNA on the growth and metastasis of human prostate cancer cells
Authors: B.K. Li, K. Guo, C.Y. Li, H.L. Li, P.P. Zhao,K. Chen,C.X. Liu
This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cyto.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.28
- DOI:
- 10.4238/2015.December.1.28
Detecting circulating tumor cells in patients with advanced non-small cell lung cancer
Authors: Y.H. Xu, J. Zhou and X.F. Pan
We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease pa.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.1.1
- DOI:
- http://dx.doi.org/10.4238/2015.September.1.1
XPG polymorphisms are associated with prognosis of advanced non-small cell lung cancer treated with platinum-based doublet chemotherapy
Authors: H.Z. Zou and Y.Q. Zhao
We conducted a cohort study to investigate whether 3 potential single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene could predict the survival of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet chemotherapy. We enrolled 262 patients with histologically confirmed NSC.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.3
- DOI:
- 10.4238/2015.January.26.3
In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells
Authors: S.J. Peng, J. Li, Y. Zhou, M. Tuo, X.X. Qin, Q. Yu, H. Cheng and Y.M. Li
Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029434
- DOI:
- 10.4238/gmr16029434
Apoptosis in different gastric lesions and gastric cancer: relationship with Helicobacter pylori, overexpression of p53 and aneuploidy
Authors: A.C. Targa, A.C.G. C�©sar, P.M. Cury, A.E. Silva
Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal metaplasia, and stomach tumorigenesis. Thus, the aim of the present study was to investigate the frequency of ap.. Read More»
- Genet. Mol. Res. 6(3):
DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity
Authors: M. Santos, L.L. Maia, C.V.M. Silva, G.T. Peterle, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively regulates autophagy, which has been associated with the development and progression of several diseases, such as cance.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.13