Cancer
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response
Authors: L. Yang, X.W. Wang, L.P. Zhu, H.L. Wang, B. Wang, T. Wu, Q. Zhao, D.L.X.T. JinSiHan and X.Y. Wang
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorph.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038679
- DOI:
- 10.4238/gmr.15038679
Effect of miRNA-203 on cervical cancer cells and its underlying mechanism
Authors: X.Z. Yin, D.M. Zhao, G.X. Zhang and L. Liu
miRNA-203 is involved in the development and progression of various types of cancer. However, its role in cervical cancer remains unclear. The aim of this study was to investigate the effect of miRNA-203 on the proliferation and migration of HeLa cervical cancer cells, as well as survivin expression in these cells. A miRNA-203 primer probe was designed ac.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038680
- DOI:
- 10.4238/gmr.15038680
Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma
Authors: J. Liu, X.Y. Yang and W.J. Shi
Non-small cell lung carcinoma, NSCLC, accounts for 80-85% of lung cancers. NSCLC can be mainly divided into two types: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The purpose of our study was to identify and differentiate the pathogenesis of ADC and SCC at the molecular level. The gene expression profiles of ADC an.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.8
- DOI:
- 10.4238/2014.January.8.8
-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race
Authors: S. Mandal, F. Abebe and J. Chaudhary
Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation cou.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.5
- DOI:
- 10.4238/2014.January.10.5
Biochip analysis of prostate cancer
Authors: M.Q. Fan, P.X. Wang, J.Y. Feng, Y. Xiao and C.B. Huang
Microarray expression analysis was used to forecast the roles of differentially co-expressed genes (DCG) and DCG and links in the pathogenesis of prostate cancer. In addition, we demonstrate that the relationship between transcriptional factors (TFs) and their targets can be considered a key factor in determining the differenc.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.6
- DOI:
- 10.4238/2014.January.10.6
A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women
Authors: F. Chen, J. Zhou, Y. Xue, S. Yang, M. Xiong, Y. Liand Q. Liu
A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We gen.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.9
- DOI:
- 10.4238/2014.January.10.9
Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis
Authors: Y. Wang and T.T. Zeng
Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.21.11
- DOI:
- 10.4238/2014.February.21.11
Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis
Authors: M. Zhai, Y. Wang and M.F. Jiang
Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.19
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.19
NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental factors can also increase the ris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.19.3
- DOI:
- 10.4238/2014.March.19.3
Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy
Authors: Zhang, W. Ma, Y. Li, J. Wu and G.Y. Shi
Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors. We investigated the impact of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp, and XPD Lys751Gln gene polymorphisms on tre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.2
- DOI:
- 10.4238/2014.January.14.2