Cancer
Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer
Authors: Z.Q. Wang,X.L. Sun,H.L. Su,X.F. Liu,Y.J. Xuan,S.Q. Yu
We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.5
- DOI:
- 10.4238/2015.December.1.5
Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians
Authors: J.W. Fu, X.Q. Chu
The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wan.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.11
- DOI:
- 10.4238/2015.December.1.11
Prospective analysis of KRAS wild-type patients with metastatic colorectal cancer using cetuximab plus FOLFIRI or FOLFOX4 treatment regimens
Authors: M.Y. Huang, M.J. Chen, H.L. Tsai, C.H. Kuo, C.J. Ma, M.F. Hou, S.C. Chuang, S.R. Lin and J.Y. Wang
Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor, has proven to be efficient in the treatment of metastatic colorectal cancer. We made a prospective study of the efficacy and toxicities of cetuximab-combination first-line (FOLFOX4) versus second/third-line (FOLFIRI) chemotherapy in 98 KRAS wildtype p.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.4
- DOI:
- 10.4238/2011.October.3.4
Association of ADH1B Arg47His and ALDH2 Glu487Lys polymorphisms with risk of colorectal cancer and their interaction with environmental factors in a Chinese population
Authors: Q. Zhong, R.R. Wu and Z.M. Zeng
Human colorectal cancer (CRC) is a major worldwide health concern, and its development has been shown to be associated with alcohol intake. We carried out a study to investigate the effect of the ADH1B Arg47His and ALDH2 Glu487Lys genetic polymorphisms and their interaction with alcohol consumption on development of CRC. Between March 2013 and May 2015, a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038682
- DOI:
- 10.4238/gmr.15038682
Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity
Authors: M.Y. Li, M. Zhu, F. Feng, F.Y. Cai, K.C. Fan, H. Jiang, Z.Q. Wang and E.Q. Linghu
The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and meta.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.13
- DOI:
- 10.4238/2014.April.14.13
Loss of heterozygosity on chromosome 5 in Iranian esophageal cancer patients
Authors: F. Attaran-Bandarabadi, A.A. Ziaee, M. Yazdanbod, M. Shahpanah, A. Setayeshgar and M. Nassiri
There is a high incidence of esophageal squamous cell carcinoma (ESCC) in Iran. Non-functionality of some tumor suppressor genes has been reported in esophageal cancer. Loss of heterozygosity on chromosome 5 has also been reported in esophageal carcinomas. We assessed loss of heterozygosity along a region of the long arm of ch.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.5.2
- DOI:
- 10.4238/2011.October.5.2
Meta-analysis of the relationship between p21 Ser31Arg polymorphism and lung cancer susceptibility
Authors: G. Lin, F. Fang, X.-J. Yu and L. Yu
The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stra.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.13.2
- DOI:
- 10.4238/2011.October.13.2
Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin
Authors: J.R. Pesarini, S.G. Victorelli, A.P. Vicentini, L.K. Ferreira, M.O. Mauro, R. Matuo, J.R. Oliveira, A.C.M.B. Antoniolli, M.S. Mantovani and R.J. Oliveira
We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150,.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.2.11
- DOI:
- 10.4238/2014.July.2.11
Interleukin-6 -572G/C polymorphism and prostate cancer susceptibility
Authors: W.J. Huan, L.J. Wu, Z.C. Min, L.T. Xu, C.M. Guo, Z.P. Chen, X.J. Lou, B. Xu3and B.D. Lv
Strong evidence suggests that cancer-associated inflammation promotes tumor growth and progression, and interleukin-6 (IL6) is an important modulator of inflammation. However, the roles of IL6 and mutations of its corresponding gene in prostate cancer have not been clearly documented. We retrieved data from the Oncomine database concerning IL6 expression .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037563
- DOI:
- 10.4238/gmr.15037563
Association between the CDH1-472delA and -160C>A polymorphisms and diffuse and intestinal gastric cancer in a Mexican population
Authors: A.R. Bustos-Carpinteyro, N. Delgado-Figueroa, E. Santiago-Luna, M.T. Maga�±a-Torres and J.Y. S�¡nchez-L�³pez
Gastric cancer (GC), the third leading cause of cancer-related deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs162.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038715
- DOI:
- 10.4238/gmr.15038715