Cancer
MDR1 C3435T polymorphism in Mexican patients with breast cancer
Authors: N.M. MacÃ?Âas-GÃ?³mez, M. GutiÃ?©rrez-Angulo, E. Leal-Ugarte, L. RamÃ?Ârez-Reyes, J. Peregrina-Sandoval, J.P. Meza-Espinoza, F. Ramos Solano, M. de la Luz Ayala-Madrigal and F. Santoyo Telles
We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (Méx.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.17
- DOI:
- 10.4238/2014.July.4.17
Effect of specific silencing of EMMPRIN on the growth and cell cycle distribution of MCF-7 breast cancer cells
Authors: X.Q. Yang, J. Yang, R. Wang, S. Zhang, Q.W. Tan, Q. Lv, W.T. Meng, X.M. Mo, H.J. Li
The extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the immunoglobulin family and shows increased expression in tumor cells. We examined the effect of RNAi-mediated EMMPRIN gene silencing induced by lentiviral on the growth and cycle distribution of MCF-7 breast cancer cells. Lentiviral expressin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.24
- DOI:
- 10.4238/2015.December.1.24
Prevention of DNA damage and anticarcinogenic activity of Activia�® in a preclinical model
Authors: S.M.A. Limeiras, F.M. Ogo, L.A.L. Genez, C.M. Carreira,E.J.T. Oliveira, L.R. Pessatto, S.C. Neves, J.R. Pesarini, L.C. Schweich, R.A. Silva, W.B. Cantero, A.C.M.B. Antoniolli-Silva, R.J. Oliveira
Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria comb.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019492
- DOI:
- 10.4238/gmr16019492
Serum miR-200c expression level as a prognostic biomarker for gastric cancer
Authors: H.-P. Zhang,F.-B. Sun, S.-J. Li
The aim of the present study was to analyze the serum expression level of microRNA-200c (miR-200c) in gastric cancer (GC) patients and to determine the relationship between this expression and clinicopathological features and survival. Serum samples were obtained from 98 patients with GC between February 2008 and January 2013... Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.2
- DOI:
- 10.4238/2015.December.7.2
Prognostic role of microRNA-100 in patients with bladder cancer
Authors: Y.H. Cao, H.H. Zhang,H.F. Xu, Y.J. Duan, Q. Li, B. Huang
We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the K.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.6
- DOI:
- 10.4238/2015.December.7.6
Correlation of ERCC1 expression in peripheral blood lymphocytes with outcomes of patients with gastric cancer treated with oxaliplatin-based adjuvant chemotherapy
Authors: Y.Y. Zhang, K.S. Gu, H.Y. Wu,F. Yang, L.J. Bu, C.C. Zhao,Y.R. Zhang
Excision repair cross-complementing gene-1 (ERCC1) is a key regulatory enzyme whose expression patterns in tumor tissues are associated with survival in gastric cancer. The present study aimed to evaluate the effects of ERCC1 expression in peripheral blood lymphocytes (PBLs) on the outcome of patients with gastric cancer treat.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.3
- DOI:
- 10.4238/2015.December.7.3
Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer
Authors: G. Chen, S.Y. Li, H.Y. Cai and F.Y. Zuo
The aim of this study was to investigate the expression of glycosylphosphatidylinositol anchor attachment protein 1 (GPAA1) and its significance in patients with colorectal cancer. Fifty-two patients with primary colorectal cancer were included in this study. GPAA1 expression was detected by immunohistochemistry, reverse trans.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.19
- DOI:
- 10.4238/2014.January.21.19
Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking
Authors: T.M. Silva, C.R. Marques, M.F. Marques Filho, A.B. Marques,G. Di Pietro and F. Rios-Santos
Polymorphisms in genes encoding xenobiotic-metaboli- zing enzymes might explain differences in the susceptibility to upper aerodigestive tract (UADT) cancers in individuals exposed to tobacco or other carcinogens. The present study aimed to evaluate the association of polymorphisms in the glutathione S-transferase (GST) candid.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.22
- DOI:
- 10.4238/2014.January.21.22
Role of VEGF gene polymorphisms in the clinical outcome of non-small cell lung cancer
Authors: N. Chen, C.N. Ma, M. Zhao, Y.J. Zhang
This report details a study conducted to assess the role of VEGF gene polymorphisms in the prognosis of advanced non-small cell lung carcinoma (NSCLC). Samples obtained from 210 advanced NSCLC patients admitted at the Huaihe Hospital of Henan University between January 2010 and December 2011 were recruited for this study. The .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.13
- DOI:
- 10.4238/2015.December.7.13
Association of tumor necrosis factor-�± 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis
Authors: J. Cai,M.Y. Yang, N. Hou, X. Li
We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Sci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.22
- DOI:
- 10.4238/2015.December.7.22