Cancer
Null polymorphisms in GSTT1 and GSTM1 genes and their associations with smoking and cervical cancer
Authors: Ana L�?ºcia Munaro Tacca, Ana Karolina Lopes, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Marcio Teodoro Cordeiro Silva, Sergio Henrique Nascente Costa, Nathalia Amaral Nogueira, Jessica Enocencio Porto Ramos, Andrea Alves Ribeiro, Vera Aparecida Saddi
Human Papillomavirus (HPV) infection is the main risk factor for cervical cancer. However, other risk factors include smoking and genetic susceptibility. Glutathione-S-Transferases (GST) is enzymes involved in tobacco carcinogens metabolism and genes encoding these enzymes are highly polymorphic. The objective of this study wa.. Read More»
- Genet. Mol. Res. 17(2):
- http://dx.doi.org/gmr16039918
- DOI:
- http://dx.doi.org/10.4238/gmr16039918
The Disruption of Klf6-Related Super-Enhancer Induces Growth Inhibition and Apoptosis in Human HepG2 Cells
Authors: KumChol Ri, KumChol Kim, SunHyok Kong, JuHua Ri
Klf6 is a member of the Krüppel-like factor family, which is a group of zinc finger transcription factors involved in differentiation and development. In general, Klf6 gene plays an important role in growth-related signal transduction pathways, cell proliferation, apoptosis, and angiogenesis. Recently, the Klf6 gene is co.. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039888
- DOI:
- 10.4238/gmr16039888
Role of KRAS in NSCLC: present and future
Authors: Addeo A, Bini R
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite therapeutic advances over the last several decades, the overall 5-year survival remains only 16%. (Siegel R, 2013). Molecular studies have indicated that Adenocarcinomas have distinct genomic alterations allowing classification into clinically relevan.. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039873
- DOI:
- 10.4238/gmr16039873
Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine
Authors: Fehmida Bibi, Peter Natesan Pushparaj, Muhammad I. Naseer, Muhammad yasir, Esam I. Azhar
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers, including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expre.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039845
- DOI:
- 10.4238/gmr16039845
Association between polymorphisms in TLR4 gene targeted by microRNA-140 and cervical precancerous lesion in south Chinese women: a case control study
Authors: Chuican Huang , Zhongyi Li , Xingming Zhong, Yao Wang, Xingguang Ye, Lipeng Jing, Shiqi Huang, Qian Yin , Zhulin Miao, Zixing Zhou, Yang Liu, Xiaohong Ye, Yajing Han, Meiling Ou, Di Xiao , Congcong Guo, Chengli Zeng, Guang Yang, Chunxia Jing, Xiangcai Wei
Toll-like receptor 4 (TLR4), one of the key immune system effectors, plays a main role in immune recognition of cervical cancer. Micro-RNAs are involved in regulation of multiple important genes in the progression of cervical cancer. A case-control study of 592 people was conducted from Yun’an County, Yunfu City, Guangdo.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039831
- DOI:
- 10.4238/gmr16039831
Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features
Authors: J.T. Takamori, M. Santos, G. T. Peterle, L. Rossi, O. A. Curioni, D. Gazito, L. L. Maia, I. D. Louro, M. M. de Oliveira, J. G. dos Santos, R. A. Moyses, P. M. Cury, T. N. Toporcov, J. L. Kanda, A. M. A. da Silva, M. B. de Carvalho
Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of oral cancer by interfering with mechanisms of DNA synthesis and repair. From a genetic s.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039829
- DOI:
- 10.4238/gmr16039829
Clinical and molecular findings in an Albanian family with familial adenomatous polyposis
Authors: P. E. Maltese, G. Di Saverio, E. Manara, F. Fanelli, N. Capodicasa, D. Guraj, I. Shehaj, B. Amato, A. Babameto-Laku, S. Michelini , M. Bertelli
Purpose: Familial adenomatous polyposis is an inherited precancerous condition characterized by multiple colorectal polyps. This brief report describes three generations of a family with a history of colorectal cancer in which genetic testing was useful for detecting individuals at risk. Methods: A next generation sequencing c.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039823
- DOI:
- 10.4238/gmr16039823
DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer
Authors: T.D. Silva, A.V. Felipe, V.M. Vidigal, S.S. Saad, N.M. Forones
Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissu.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039816
- DOI:
- 10.4238/gmr16039816
Association between gastrointestinal cancers and fingerprint patterns in the Iranian population
Authors: S. Abbasi and M. Rasouli
Gastrointestinal cancers are malignant diseases with high mortality rate. Early diagnosis of patients could improve the results of treatment. Many studies used dermatoglyphics as a biomarker to predict the incidence of genetic diseases and cancers. This study assessed the association between gastrointestinal cancers and partic.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039762
- DOI:
- 10.4238/gmr16039762
Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer
Authors: A.Q. Niu, Y.H. Cao, H. Wang, X. Zhang, B. Zhu and Z.H. Li
Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038826
- DOI:
- 10.4238/gmr16038826