Cancer
MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer
Authors: Q.W. Li,T. Zhou, F. Wang,M. Jiang, C.B. Liu, K.R. Zhang, Q. Zhou, Z. Tian, K.W. Hu
It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using q.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.2
- DOI:
- 10.4238/2015.December.8.2
Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer
Authors: X.P. Huang, W.H. Zhou and Y.F. Zhang
Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise e.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.24.17
- DOI:
- 10.4238/2014.January.24.17
Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer
Authors: H. Yang, G. Li and W.F. Li
We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymeras.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.13
- DOI:
- 10.4238/2015.January.30.13
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma
Authors: H.B. Liu, Y. Zhu, Q.C. Yang, Y. Shen, X.J. Zhang and H. Chen
We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. AD.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.April.30.12
- DOI:
- 10.4238/2015.April.30.12
Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray
Authors: F.H. Bai, N.J. Wang, J. Wang, L. Yang, F.M. Zhang, F. Yin, J. Liang, K.C. Wu and D.M. Fan
With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared f.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.25.1
- DOI:
- 10.4238/2012.June.25.1
Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer
Authors: F.Q. Li, B. Xu, Y.J. Wu Z.L. Yang and J.J. Qian
Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.17
- DOI:
- 10.4238/2015.January.30.17
Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer
Authors: H.-T. Zhang, Y. Xu, Z.-H. Zhang and L. Li
Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise est.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.13
- DOI:
- 10.4238/2012.June.15.13
Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population
Authors: S.G. Liu, L. Ma, Q.H. Cen, J.S. Huang, J.X. Zhang and J.J. Zhang
Genome-wide association studies in several ethnic groups have reported that polymorphisms of the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes, located on 5p15.33, are associated with susceptibility to lung cancer. However, whether genetic variants of TERT-CLPTM1L are associated with an increased ris.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.4
- DOI:
- 10.4238/2015.May.4.4
Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer
Authors: M.S. Monteiro, D.B. Vilas Boas, C.B. Gigliotti and D.M.F. Salvadori
Endometriosis is a complex disease that has both benign and malignant characteristics. It affects 5-10% of women of reproductive age. Studies have demonstrated the existence of common genetic changes in endometriosis and ovarian cancer, suggesting a possible association between these 2 diseases. However, the mechanisms that le.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.9
- DOI:
- 10.4238/2014.January.28.9
Expression of EpCAM and Wnt/ �²-catenin in human colon cancer
Authors: F.Q. Zhou, Y.M. Qi, H. Xu, Q.Y. Wang, X.S. Gao and H.G. Guo
The aims of this study were to explore the correlation between the expression of EpCAM and the Wnt/β-catenin pathway in human colon cancer and its clinical significance for the evaluation of cancer prognosis. Samples from colon cancer, para-carcinoma, or benign intestinal tissue from individual patients (50) and from normal intestinal mucosal tissues.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.6
- DOI:
- 10.4238/2015.May.4.6