Cancer
Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence
Authors: L.N. Moraes, M.F. Borges, P.A.C. Sousa, P.C. Venere and I.L. Souza
Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an unusually high incidence of .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.10
- DOI:
- 10.4238/2012.June.15.10
A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese
Authors: L.Q. Shen, Y.Z. Xie, X.F. Qian, Z.X. Zhuang, Y. Jiao and X.F. Qi
Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let- 7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes i.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.8
- DOI:
- 10.4238/2015.May.4.8
Cumulative methylation alternations of gene promoters and protein markers for diagnosis of epithelial ovarian cancer
Authors: B.L. Xing, T. Li, Z.H. Tang, L. Jiao, S.M. Ge, X. Qiang and J. OuYang
DNA methylation plays an important role in carcinogenesis and cancer development. In this study, we examined gene methylation in epithelial ovarian cancer (EOC) using cationic conjugated polymer (CCP)-based fluorescence resonance energy transfer (FRET) to evaluate the application of cumulative methylation alternations of genes associated with cancer antig.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.11
- DOI:
- 10.4238/2015.May.4.11
Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery
Authors: X.-X. Liu and F.-J. Liu
Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tiss.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.14
- DOI:
- 10.4238/2015.May.4.14
Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient
Authors: S. Ghafouri-Fard M.H. Modarressi
The outer dense fiber (ODF) genes encode proteins that co-assemble along the axoneme of the sperm tail. Recently, it was demonstrated that some ODF genes are aberrantly expressed in tumors, including prostate adenocarcinoma, basal cell carcinoma, and chronic myeloid lymphoma. We cloned ODF3 and ODF4 cDNA from the testis of a patient suffering from prostat.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.4.11
- DOI:
- 10.4238/2012.October.4.11
Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance
Authors: M. Zhang and S.C. Luo
The aim of this study is to analyze gene expression data to identify key genes and pathways associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) and to improve clinical treatment strategies. The gene expression data set was downloaded from Gene Expression Omnibus and included 12 chemotherapy-resistant EOC samples an.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017496
- DOI:
- 10.4238/gmr.15017496
EPHX1 Tyr113His and His139Argpolymorphisms in esophageal cancer risk: a meta-analysis
Authors: X. Tan, W.W. He, Y.Y. Wang, L.J. Shi and M.W. Chen
Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) po.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.10
- DOI:
- 10.4238/2014.January.28.10
5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/�²-catenin signaling pathway
Authors: H. Zhang, W.C. Zhou, X. Li, W.B. Meng, L. Zhang, X.L. Zhu, K.X. Zhu, Z.T. Bai, J. Yan, T. Liu, X.C. Xu and Y.M. Li
5-Azacytidine has been shown to be an effective anti-pancreatic cancer drug, but the mechanism remains unknown. In the current study, we explored the effect of 5-azacytidine on abnormal activation of the Wnt-β-catenin signaling pathway in pancreatic cancer cells. The human pancreatic cancer cell line Bxpc-3 was treated wi.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.22
- DOI:
- 10.4238/2014.July.4.22
Setup errors in cone-beam computed tomography and their effects on acute radiation toxicity in cervical cancer radiotherapy
Authors: S. Xin
This study aimed to evaluate cone-beam computed tomography setup errors during cervical cancer treatment and the effects of these errors on acute radiation toxicity and treatment efficacy. A total of 170 cervical cancer patients were randomly divided into image-guided radiation therapy (IGRT; 86 patients) and intensity-modulated radiation therapy (IMRT; 8.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.4
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.4
Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer
Authors: L. Qi, L.N. Xing, X. Wei and S.G. Song
This study aimed to investigate the inhibition of vascular endothelial growth factor (VEGF) by small hairpin RNA (shRNA) interference combined with radiotherapy on the growth of cervical cancer SiHa cell xenografts in nude mice. The effective pVEGF-shRNA plasmid was screened by reverse transcription-polymerase chain reaction (.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.2
- DOI:
- 10.4238/2014.July.7.2