Cancer
Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population
Authors: R. Zhao and M.F. Ying
We conducted a case-control study to investigate the role of ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphisms in the development of breast cancer. Between March 2012 and March 2014, a total of 242 newly diagnosed breast cancer patients with histopathologically confirmed primary breast cancer and 242 healthy controls were recruited. Genotyping of ERCC1.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017263
- DOI:
- 10.4238/gmr.15017263
Evaluation of cancer records from 2000-2004 in Denizli, Turkey
Authors: A. K�¶ksal H.��. Sorkun H. Demirhan A.G. Tomatir T. Alan F. ��zerdem
Objective information about cancer incidence is important for planning control programs. We examined the distribution of cancer cases recorded in Denizli province, Turkey. A total of 2185 cancer cases reported to the Denizli Province Health Ministry’s Cancer Early Diagnosis Center during the years 2000-2004 were evaluate.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr533
- DOI:
- 10.4238/vol8-1gmr533
Prognostic significance of long non-coding RNA MALAT-1 in various human carcinomas: a meta-analysis
Authors: J. Wang1*, A.M. Xu1*, J.Y. Zhang1*, X.M. He2, Y.S. Pan1, G. Cheng1, C. Qin1,L.X. Hua1 and Z.J. Wang1
The long non-coding RNA MALAT-1 plays an important role in cancer prognosis. The present research aimed to elucidate its precise predictive value in various human carcinomas. A quantitative meta-analysis was performed by searching PubMed, Embase, Web of Science, and Cochrane Library (most recently, January 2015) databases, and extracting data from studies.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017433
- DOI:
- 10.4238/gmr.15017433
Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Authors: Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.2
- DOI:
- 10.4238/2012.November.12.2
Gene and protein expression in the oxaliplatin-resistant HT29/L-OHP human colon cancer cell line
Authors: Z. Xiang, Q.J. Kang and X. Xiang
Oxaliplatin (L-OHP) is one of the most commonly used anticancer drugs in adjuvant treatment of colon cancer after complete resection of the primary tumor and treatment of metastatic colorectal cancer. Cancer cells eventually become resistant to L-OHP, which diminishes its curative effect. However, the mechanism of action of L-OHP remains unknown. In this .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.14
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.14
Gene expression profile in breast cancer comprising predictive markers for metastatic risk
Authors: S. Sirirattanakul, P. Wannakrairot, T. Tencomnao and R. Santiyanont
Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive marker.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.3
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.3
Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
Authors: P.K. Mishra A. Bhargava G.V. Raghuram S. Gupta S. Tiwari R. Upadhyaya S.K. Jain K.K. Maudar
Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as i.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr544
- DOI:
- 10.4238/vol8-1gmr544
Specific BRCA1 gene variations amongst young Moroccan breast cancer patients
Authors: A. Tazzite, S. Nadiffi, D. Kottwitz, M. El Amrani, H. Jouhadi,A. Benider, A. Moumen4 and H. Sefrioui
Germline mutations in the BRCA1 gene are known predictive markers for the development of hereditary breast cancer. Nevertheless, no comprehensive study has been performed targeting the presence and relevance of BRCA1 mutations in Moroccan breast cancer patients. We here present an analysis of BRCA1 gene regions (exon 2 and exo.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.31.5
- DOI:
- http://dx.doi.org/10.4238/2014.January.31.5
Association between the epithelial cadherin -160C/A gene polymorphism and diffuse gastric cancer risk: a meta-analysis.
Authors: X.W. Chen, J.X. Sun, Z.N. Wang, P. Gao, Y.X. Song, J.F. Cao, B. Liu and H.M. Xu
Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of rel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.13.3
- DOI:
- http://dx.doi.org/10.4238/2014.February.13.3
Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis
Authors: S. Yan Y.Z. Li J.W. Zhu C.L. Liu P. Wang Y.L. Liu
We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.26.1
- DOI:
- 10.4238/2012.November.26.1