Cancer
Plasma human mammaglobin mRNA associated with poor outcome in patients with breast cancer
Authors: G.-W. Lee J.-Y. Kim E.-H. Koh D. Kang D.S. Choi K.-Y. Maeng J.-S. Lee
Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determin.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.28.2
- DOI:
- 10.4238/2012.November.28.2
Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study
Authors: B.-L. Shen, Q.-S. Qu, S.-Z. Miao and Y.-X. Zhang
We conducted this case-control study to assess the role of the VEGF -2578C/A, +1612G/A, +936C/T and -634G/C gene polymorphisms in the development of renal cell carcinoma (RCC). A hospital-based case-control study was conducted in a 360 consecutive primary RCC patients and 360 age and gender-matched controls during January 2010 and January 2014. The polyme.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.5
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.5
Absolute quantification of free tumor cells in the peripheral blood of gastric cancer patients
Authors: N. Bayat, M.M. Mokhtari, M. Rezaei-Tavirani, A. Baradaran-rafii, S. Rahman Zadeh, S. Heidari-Keshel and F. Ghasemvand
Gastric cancer remains the third most common cancer in the world. Metastatic disease is a major cause of death in about half of the patients; therefore, early diagnosis is crucial for successful outcome. This study applied a sensitive method for the detection of circulating tumor cells using specific tumor markers for early de.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.16.1
- DOI:
- http://dx.doi.org/10.4238/2014.June.16.1
FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma
Authors: G.T. Peterle, M. Santos, S.O. Mendes, P.B. Carvalho-Neto, L.L. Maia, E. Stur, L.P. Agostini, C.V.M. Silva, L.O. Trivilin, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
Currently, the most important prognostic factor in oral squamous cell carcinoma (OSCC) is the presence of regional lymph node metastases, which correlates with a 50% reduction in life expectancy. We have previously observed that expression of hypoxia genes in the tumor inflammatory infiltrate is statistically related to prognosis in OSCC. FAS and FASL exp.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.8
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.8
Computed tomography-guided percutaneous microwave ablation therapy for lung cancer
Authors: Y.H. Sun, P.Y. Song, Y. Guo and L.J. Sheng
This study evaluated the clinical efficacy and value of computed tomography (CT)-guided percutaneous microwave ablation therapy (PMAT) for lung cancer without surgical treatment. A total of 39 lesions in 29 patients with peripheral lung cancer were treated by CT-guided PMAT under local anesthesia. The microwave energy was 50-70 W at a frequency of 2450 MH.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.18
- DOI:
- 10.4238/2015.May.11.18
Validation of associations between ESR1 variants and breast cancer risk in Chinese cohorts
Authors: X. Li, G.Y. Yao, F.X. Li, Y.R. Qiu and X.X. Yang
Estrogen receptor-a (ER) protein plays a key role in breast carcinogenesis, and common genetic variants in the corresponding gene locus have been associated with breast cancer risk in different populations. Here, we analyzed estrogen receptor 1 (ESR1) associations in two hospital-based studies of patients from the south of China. Three single-nucleotide p.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036683
- DOI:
- 10.4238/gmr.15036683
Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population
Authors: Z.M. Zhao, C.G. Li, M.G. Hu, Y.X. Gao and R. Liu
We investigated the influence of the c.1517G>C genetic variant in the X-ray repair complementing group 1 gene (XRCC1) on pancreatic cancer (PC) susceptibility in Chinese patients. A total of 390 PC patients and 392 controls were enrolled in this case-control study. The genotypes of c.1517G>C genetic variants were determi.. Read More»
- Genet. Mol. Res. 13(2):
Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk
Authors: M.S. Li, J.L. Liu, Y. Wu, P. Wang and H. Teng
We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis res.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.3
- DOI:
- 10.4238/2011.November.29.3
Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population
Authors: M.F. Ying and R. Zhao
We conducted a case-control study to investigate the role of ERCC1-ERCC5 gene polymorphisms in the risk of pancreatic cancer. This study included 195 patients who were newly diagnosed with histopathologically confirmed primary pancreatic cancer, and 254 controls were recruited from Sir Run Run Shaw Hospital, between January 2012 and December 2014. Genotyp.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017273
- DOI:
- 10.4238/gmr.15017273
Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China
Authors: Y. Fang, H.Y. Yang, Y.H. Shi, J.H. Cui, L.Y. Li, Y.C. Xu and J.L. Shao
Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactorsin the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.6
- DOI:
- 10.4238/2015.May.12.6