Cancer

Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis

Authors: H.Y. Cao, S. Wang, Z.Y. Zhang and J.Y. Lou

The TP53 5'-untranslated region flanking the gene WRAP53 (also known as WDR79 and TCAB1) has been hypothesized to be associated with cancer risk due to its critical function in regulating p53 levels. In this review, we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies, compris.. Read More»

Genet. Mol. Res. 15(3):

gmr.15037976

DOI:

10.4238/gmr.15037976

Effects of the Zhikang capsule on healing of the flap after radical breast cancer surgery

Authors: C. Cheng, Y. Lv, E. Zhang, T. Yan, C. Li, D.-X. Hou and J.-H. Li

This study aimed to investigate the effect and mechanism of trauma flap healing promoted by the Zhikang capsule after radical breast cancer surgery. The enrolled breast cancer patients were randomly divided into two groups: treatment and observation. The patients in the treatment group were treated with the Zhikang capsule in addition to the conventional .. Read More»

Genet. Mol. Res. 14(2):

2015.May.18.2

DOI:

10.4238/2015.May.18.2

Abnormal expression of PTEN and PIK3CA in pemetrexed-resistant human pancreatic cancer cell line Patu8988

Authors: X. Shi, H.T. Gu, S.B. Lin, Y. Zhang, J. Yang and C.J. Qian

The aim of this study was to investigate the expression of PTEN and PIK3CA in the pemetrexed-resistant human pancreatic cancer cell line Patu8988, and to evaluate their effects on the biological behavior of pancreatic cancer cells. PTEN and PIK3CA gene and protein expressions were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and we.. Read More»

Genet. Mol. Res. 15(3):

gmr.15036991

DOI:

10.4238/gmr.15036991

Association between rs9904341 G

.. Read More»

Genet. Mol. Res. 14(2):

2015.May.18.10

DOI:

10.4238/2015.May.18.10

Effect of calcitonin on anastrozole-induced bone pain during aromatase inhibitor therapy for breast cancer

Authors: P. Liu, D.Q. Yang, F. Xie, B. Zhou and M. Liu

This study aimed to investigate calcitonin as an effective therapy for osteoporosis in patients with bone pain during the anastrozole treatment of breast cancer. Ninety-one patients, who were on anastrozole treatment for breast cancer and also suffered anastrozole-induced bone pain, were randomly divided into two groups: the c.. Read More»

Genet. Mol. Res. 13(3):

2014.July.24.7

DOI:

10.4238/2014.July.24.7

Predictive role of RRM1 and BRCA1 mRNA expression on the clinical outcome of advanced non-small cell lung cancer

Authors: J.G. Liang, Z.Y. Jin, X.D. Gao, M.R. Te, L.H. Ge and C.L. Wang

This study aimed to evaluate the association between RRM1 and BRCA1 expressions and the therapeutic efficacy of platinum-based chemotherapy in non-small cell lung cancer patients in terms of their response and prognosis. In total, 377 patients agreed to participate in our study, and all of them received plati.. Read More»

Genet. Mol. Res. 13(3):

2014.July.24.8

DOI:

10.4238/2014.July.24.8

The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis

Authors: F. Yan, R. Wang and L. Geng

Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible st.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038172

DOI:

10.4238/gmr.15038172

Clinical three-dimensional conformal radiotherapy research using repeated computed tomography scans for field reduction in older non-small-cell lung cancer patients

Authors: Z.Z. Fu, T. Gu, S.H. Zhang, X.Y. Cao, Q.H. Zhang, Y.Q. Zhang, H.X. Hua, S. Yang, P. Li and Z. Zhang

This study investigated the curative and toxic effects of three-dimensional conformal radiotherapy (3D-CRT), using repeated CT scans for field reduction in older non-small-cell lung cancer (NSCLC) patients. 3D-CRT was administered to 36 older patients with NSCLC, and irradiation fields included the primary lesion and metastati.. Read More»

Genet. Mol. Res. 13(3):

2014.July.24.13

DOI:

10.4238/2014.July.24.13

Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort

Authors: Z. Li, W.T. Yuan, S.J. Ning and S.J. Zhang

The aim of this study was to test for the possible association between vitamin D receptor (VDR) genetic variants and susceptibility to gallbladder cancer (GBC). A total of 291 GBC cases were recruited and 396 gender- and age-matched healthy volunteers were enrolled as controls. The VDR gene polymorphisms were determined in all.. Read More»

Genet. Mol. Res. 13(3):

2014.July.24.18

DOI:

10.4238/2014.July.24.18

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

Authors: L. Zhang, J. Sun, J.Q. Zhang, M. Yang, G. Bai and X.L. Ma

This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esoph.. Read More»

Genet. Mol. Res. 13(3):

2014.July.24.21

DOI:

10.4238/2014.July.24.21