Cancer
Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression
Authors: B.S. Wang, Z. Liu, W.X. Xu and S.L. Sun
MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.22
- DOI:
- 10.4238/2014.July.24.22
Association of dietary intake of folate and MTHFR genotype with breast cancer risk
Authors: Z.G. Wang, W. Cui, L.F. Yang, Y.Q. Zhu and W.H. Wei
We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population. A 1:1-matched case-control study was conducted. Two hundred and thirty patients who were newly diagnosed and histologically confirmed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.24
- DOI:
- 10.4238/2014.July.24.24
Association between the X-ray repair cross-complementing group 1 Arg194Trp polymorphism and thyroid carcinoma susceptibility: A meta-analysis
Authors: J.Z. Zhao, X.R. Tan, M. Zhao, X.C. Mao and L. Jiang
Previous case-control studies having investigated the relationship between the X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and thyroid cancer (TC) have drawn inconsistent conclusions. The current study aimed to clarify the role of this polymorphism in susceptibility to TC. An up-to-date search of PubMed and Web of Science datab.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037793
- DOI:
- 10.4238/gmr.15037793
Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population
Authors: W.M. Zhao, P. Shayimu, L. Liu, F. Fang and X.L. Huang
We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospital-based case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 20.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037864
- DOI:
- 10.4238/gmr.15037864
Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells
Authors: Z.Y. Guo, G.D. Yao, L.P. Fu, Z.G. Fu and B. Hou
The aim of this study was to observe the effects of recombinant human endostatin on the proliferation and apoptosis of mouse gastric cancer cells, and explore some possible mechanisms of recombinant human endostatin inhibition of cancer. A murine gastric cancer xenograft model was established. A total of 20 mice were divided into two groups (control and e.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.17
- DOI:
- 10.4238/2015.May.18.17
1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients
Authors: S.A. Gutierrez-Rubio, A. Quintero-Ramos, A. Dur�¡n-C�¡rdenas,R.A. Franco-Topete, J.M. Castro-Cervantes, A. Oceguera-Villanueva, L.M. Jim�©nez-P�©rez, L.M.A. Balderas-Pe�±a, G. Morgan-Villela,A. Del-Toro-Arreola and A. Daneri-Navarro
MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association bet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.3
- DOI:
- 10.4238/2015.February.13.3
Association between B7-H1 expression and bladder cancer: a meta-analysis
Authors: Y.U. Wang, A.N.G. Liu and S.H.A.N. Zhao
B7 homolog 1 (B7-H1), which is also known as programmed death-L1, is an important member of the B7/CD28 costimulatory factor superfamily, which are emerging as important mediators of various host immune responses. B7-H1 is differentially expressed in various cell subsets and to different extents in human and murine cells. Human B7-H1 is constitutively exp.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.6
- DOI:
- 10.4238/2015.February.13.6
Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer
Authors: Y. Li, H.Z. Qin, Q. Song, X.D. Wu and J.H. Zhu
Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Expression and role of cyclophilin B in stomach cancer
Authors: D.Q. Meng, P.L. Li and M. Xie
We elucidated the expression of ciclosporin protein B (cyclophilin B) in stomach cancer tissue and the correlation between cyclophilin B and clinicopathological parameters, and determined the effect of cyclophilin B on growth and proliferation of stomach cancer cells. Pathological sections of stomach cancer and paracancerous tissue were collected for dete.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.5
- DOI:
- 10.4238/2015.May.22.5
Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer
Authors: Y. Dong, J.W. Liu, Y.J. Gao, T. Zhou and Y.M. Chen
We examined the relationships between singlenucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therap.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.8
- DOI:
- 10.4238/2015.May.22.8