Cancer
MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2
Authors: T. Zhang, J.G. Wan, J.B. Liu and M. Deng
The forkhead box F2 (Foxf2) gene suppresses epithelial-mesenchymal transition via the modulation of transcription of zinc finger E-box-binding homeobox 1 (Zeb1) and epithelial (E)-cadherin, thereby inhibiting tumor metastasis. Additionally, the specific binding of microRNA (miR)-200c to Foxf2 mRNA impedes metastatic pulmonary .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038971
- DOI:
- 10.4238/gmr16038971
Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions
Authors: B.S. Chagas, A.P.A.D. Gurgel, S.S.L. Paiva J�ºnior, R.C.P. Lima,M.N. Cordeiro, R.R. Moura, A.V.C. Coelho, K.C.G. Nascimento,J.C. Silva Neto, S. Crovella and A.C. Freitas
Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039742
- DOI:
- 10.4238/gmr16039742
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis
Authors: E.V.W. dos Santos, L.N.R. Alves and I.D. Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instab.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039691
- DOI:
- 10.4238/gmr16039691
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Authors: Y.X. Fan, P. Abulimiti, H.L. Zhang, Y.K. Zhou and L. Zhu
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029414
- DOI:
- 10.4238/gmr16029414
Cytogenetic aspects of a canine breast carcinosarcoma - a case report
Authors: C.S.D. Morais, P.R.A.M. Affonso, J.A. Bitencourt and A.A. Wenceslau
This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterati.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029433
- DOI:
- 10.4238/gmr16029433
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk
Authors: B.B. Sun, J.Z. Wu, Y.G. Li and L.J. Ma
Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a compr.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.17
- DOI:
- 10.4238/2014.December.4.17
S100A4 expression and prognosis of gastric cancer: a meta-analysis
Authors: Y. Wang1*, L.-B. Zhou1* and X.-H. Li2
The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform li.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.1
- DOI:
- 10.4238/2014.December.12.1
Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine
Authors: M. Zhou, Y.J. Ding, Y. Feng, Q.R. Zhang, Y. Xiang and H.Y. Wan
Xeroderma pigmentosum group D (XPD) plays a key role in the repair of DNA and platinum resistance lesions. Cytidine deaminase (CDA) genes determine the velocity of gemcitabine catalysis. This study aimed to investigate the relationship between XPD and CDA genotypes and outcome in non-small lung cancer (NSCLC) patients. We used.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.9
- DOI:
- 10.4238/2014.April.29.9