Cancer
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population J.
Authors: J.M. Liu, S.H. Cheng, C. Xia, T. Deng, Y.C. Zhu, X. Wei, Z.L. Huang, B.H. Liao, D.Y. Luo, Y.G. Zhang, T. Jin, K.J. Wang, J. Huang, H. Li
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated be.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019469
- DOI:
- 10.4238/gmr16019469
Influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy
Authors: J.P. Liu, Y.H. Zhang, B. Yang, Q. Chen and L. Cao
The aim of this study was to determine the influence of thoracic duct ligation on the lipid metabolism of patients with esophageal carcinoma after esophagectomy. A total of 74 patients with esophageal carcinoma who underwent esophagectomy were divided into 2 groups according to whether or not their thoracic duct was ligated. Thirty-nine patients were in t.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.11
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.11
Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer
Authors: L.P. Chen, P.S. Cai and H.B. Liang
Nuclear factor-kB (NF-kB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-kB gene family) is associated with increased risk of various cancers. However, only one study ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.15
- DOI:
- 10.4238/2015.July.27.15
Comparative study of clinical efficacy of laparoscopy-assisted radical gastrectomy versus open radical gastrectomy for advanced gastric cancer
Authors: L.M. Wu, X.J. Jiang, Q.F. Lin and C.X. Jian
The purpose of this study is to compare the efficacy of laparoscopy-assisted radical gastrectomy (LARG) versus that of open radical gastrectomy (ORG). Clinical data of 355 patients who underwent radical gastrectomy (160 in the LARG group and 195 in the ORG group) were analyzed retrospectively. Efficacy indices were compared and analyzed between the two gr.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.9
PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells
Authors: C.-G. Sun, J. Zhuang, W.-J. Teng, Z. Wang and S.-S. Du
We explored whether p53 upregulated modulator of apoptosis (PUMA) gene transfection could enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells. The liposome-mediated recombinant eukaryotic expression vector PUMA-pCDNA3 and empty vector plasmid were stably transfected into MCF-7 cells. Epirubicin (0.01-100 μM) was applied.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.6
- DOI:
- 10.4238/2015.May.29.6
Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression
Authors: W-J. Teng, P. Chen, F.-Y. Zhu, K. Di, C. Zhou, J. Zhuang,X.-J. Cao, J. Yang, L.-J. Deng and C.-G. Sun
We observed the influence of different concentrations of Rhizoma paridis total saponins (RPTS) on the apoptosis of colorectal cancer cells and explored the internal mechanism involved. We determined whether RPTS influences the interleukin-6 (IL-6)/Janus kinase (JAK)- signal transducer and activator of transcription-3 (STAT3) apoptosis molecular pathway an.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.11
- DOI:
- 10.4238/2015.May.29.11
Human papillomavirus infection in Brazilian women with normal cervical cytology
Authors: P.M. Miranda, B.C.V. Pitol, M.S. Moran, N.N.T. Silva, P.M. Felix, J.L. Lima-Filho, C.M. Carneiro, I.D.C.G. Silva, R.F. Carvalho, A.A. Lima, W. Be�§ak and R.C. Stocco
We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples .. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.8
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.8
Predictive value of CK20 in evaluating the efficacy of treatment and prognosis after surgery for colorectal cancer
Authors: W.X. Li, H.W. Xiao, X.Q. Hong and W.X. Niu
specimens and intraperitoneal drainage fluids, CK20 levels were lower in patients with earlier cancer stages than in those at later stages. During postoperative follow-up, serum negative CK20 patients had significantly higher 3-year survival rates than serum positive CK20 patients. All differences were statistically significant (P < 0.05). CK20 levels .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.14
- DOI:
- 10.4238/2015.May.29.14
Loss of STAG2 causes aneuploidy in normal human bladder cells
Authors: X. Li, T.W. Zhang, J.L. Tang, P.P. Fa, J.X. Lu, F.M. Qi, Z.M. Cai, C.X. Liu and X.J. Sun
The aim of this study was to determine how the function of human stromal antigen 2 (STAG2) plays an important role in proper chromosome separation. STAG2 mRNA in normal bladder cells and bladder tumor cells was evaluated by RT-PCR. The protein levels of STAG2 in normal bladder cells and bladder tumor cells were determined by western blot. A cell prolifera.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.24
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.24
Differential expression of E-cadherin gene in human neuroepithelial tumors
Authors: F.J.N. Motta, E.T. Valera, A.K.B. Lucio-Eterovic, R.G.P. Queiroz,L. Neder, C.A. Scrideli, H.R. Machado, C.G. Carlotti-Junior, S.K.N. Marie and L.G. Tone
Cadherins are cell-to-cell adhesion molecules that play an important role in the establishment of adherent-type junctions by mediating calcium-dependent cellular interactions. The CDH1 gene encodes the transmembrane glycoprotein E-cadherin which is important in maintaining homophilic cell-cell adhesion in epithelial tissues. E.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr424
- DOI:
- 10.4238/vol7-2gmr424