Cancer
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration
Authors: X.S. Li and X.L. He
Abnormal expression of the kallikrein (KLK) family of serine proteases closely correlates with onset, progression, and prognosis of endocrine gland-related malignant tumors. The aim of this study was to evaluate how downregulation of KLK12 influenced cell cycle and proliferation of the AGS gastric cancer cell line. KLK12 was d.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038452
- DOI:
- 10.4238/gmr.15038452
miR-146a and miR-196a2 polymorphisms in ovarian cancer risk
Authors: X.C. Sun, A.C. Zhang, L.L. Tong, K. Wang, X. Wang, Z.Q. Sun and H.Y. Zhang
We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of mi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038468
- DOI:
- 10.4238/gmr.15038468
MicroRNA variants and colorectal cancer risk: a meta-analysis
Authors: X.M. Pan, X. Xiao, H.J. Qin, Z. Zhang, Z.H. Li, L.B. Gao and J. Jia
Colorectal cancer (CRC) is a multi-factorial disease, and genetic background may contribute to its etiology. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may be used as specific markers of predisposition for CRC diagnosis and preventionIn this review, we summarize and discuss recent publications evaluating the .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038478
- DOI:
- 10.4238/gmr.15038478
Snail-induced epithelial-mesenchymal transition in gastric carcinoma cells and generation of cancer stem cell characteristics
Authors: Y.J. Yang, Z.B. Li, G.R. Zhang, L.J. Wu, J.Y. Yu, L.J. Hu, Y.L. Zhou, H.D. Wang and D. Liang
Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer ste.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038510
- DOI:
- 10.4238/gmr.15038510
Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression
Authors: G.-F. Li, T.-L. Qian, G.-S. Li, C.-X. Yang, M. Qin, J. Huang, M. Sun and Y.-Q. Han
Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproa.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.13.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.13.1
STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer
Authors: B. Jiang, Z.Z. Zhu, F. Liu, L.J. Yang, W.Y. Zhang, H.H. Yuan, J.G. Wang, X.H. Hu and G. Huang
Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene. However, association studies of single nucleotide polymorphisms (SNPs) in the STAT3 gene with cancer risk are rare and not available for lung cancer. We examined whether STAT3 po.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1071
- DOI:
- 10.4238/vol10-3gmr1071
Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in women with locally advanced breast cancer
Authors: F.F.O. Rodrigues, R.E. Santos, M.B. Melo, M.A.L.G. Silva, A.L. Oliveira, R.L. Rozenowicz, L.B. Ulson and T. Aoki
Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associat.. Read More»
- Genet. Mol. Res. 7(1):
A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer
Authors: X.X. Lu, J.J. Hu, Y. Fang, Z.T. Wang, J.J. Xie, Q. Zhan, X.X. Deng, H. Chen, J.B. Jin, C.H. Peng, J. Liu, H.W. Li and B.Y. Shen
Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.30
- DOI:
- 10.4238/2014.August.7.30
On the absence of mutations in nucleotide excision repair genes in sporadic solid tumors
Authors: J.C.M. Mombach, M.A.A. Castro, J.C.F. Moreira and R.M.C. de Almeida
In general, stochastic tumors show genomic instability associated with the proliferation of DNA point mutations, that is, a mutator phenotype. This feature cannot be explained by a dysfunctional mismatch repair alone, and indicates that nucleotide excision repair (NER) and/or base excision repair should be suppressed. However, mutations in NER genes are n.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr393
- DOI:
- 10.4238/vol7-1gmr393
Common polymorphisms in the HIF-1�± gene confer susceptibility to digestive cancer: a meta-analysis
Authors: J.J. Xu, L.Y. Zou, L. Yang, X.L. He and M. Sun
Recent evidence suggests that common functional polymorphisms in the hypoxia inducible factor-1α (HIF-1α) gene may play an important role in the development and progression of digestive cancer, but individually published results are inconclusive. Our meta-analysis is aimed to derive a more precise estimation of the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.5
- DOI:
- 10.4238/2014.August.15.5