Cancer

HPV genotype analysis for women in Shaanxi Province of China

Authors: J. Li, Y.Y. Wang, X.F. Tian, X. Nan, T. Yan, P. Wang, Y.L. Fu and G.Q. Wang

The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV inf.. Read More»

Genet. Mol. Res. 15(4):

gmr15047178

DOI:

10.4238/gmr15047178

RETRACTION of â�?�?Correlation analysis between an IL-6 genetic polymorphism and non-small cell lung cancer prognosisâ�?, by Zhao K, Xu J, Tian H published in Genetics and Molecular Research 15 (1): 15017021 (2016) DOI: 10.4238/gmr.15017021

Authors: Zhao K, Xu J and Tian H

Genet. Mol. Res. 15(4):

gmr150470211

DOI:

10.4238/gmr150470211

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

Authors: X.F. Chen, S. Cai, Q.G. Chen, Z.H. Ni, J.H. Tang, D.W. Xu and X.B. Wang

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-.. Read More»

Genet. Mol. Res. 11(1):

2012.February.16.2

DOI:

10.4238/2012.February.16.2

microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL

Authors: X.J. Lai, X.Y. Cheng and L.D. Hu

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A t.. Read More»

Genet. Mol. Res. 15(4):

gmr15048853

DOI:

10.4238/gmr15048853

Frequency of human papillomavirus types 16, 18, 31, and 33 and sites of cervical lesions in gynecological patients from Recife, Brazil

Authors: M.F.P.T. Baldez da Silva, V. Guimar�?£es, M.A.R. Silva, C.M. Medeiros do Amaral, W. Be�?§ak, R.C. Stocco, A.C. Freitas and S. Crovella

Human papilloma virus (HPV) is a well-established cause of cervical cancer. While many studies have been performed so far on HPV viral biology, mode of infection and prevention measures, scanty information is available on lesion sites of infected women and the incidence of viral types at specific locations. We looked for a pos.. Read More»

Genet. Mol. Res. 11(1):

2012.March.1.3

DOI:

10.4238/2012.March.1.3

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

Authors: J. Lin, R.M. Zeng, R.N. Li and W.H. Cao

Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gast.. Read More»

Genet. Mol. Res. 13(1):

2014.March.24.10

DOI:

10.4238/2014.March.24.10

Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1�?² gene and prostate cancer: a systematic review and meta-analysis

Authors: Y.Z. Xiang, S.B. Jiang, J. Zhao, H. Xiong, Z.L. Cui, G.B. Li and X.B. Jin

Polymorphism 17q12 rs4430796 within HNF1β is a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findin.. Read More»

Genet. Mol. Res. 13(3):

2014.August.28.3

DOI:

10.4238/2014.August.28.3

Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis

Authors: Y.P. Gu, Q.Y. Yuan, H. Zhang, C.J. Wang and F. Zhou

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In t.. Read More»

Genet. Mol. Res. 14(3):

2015.July.28.4

DOI:

10.4238/2015.July.28.4

Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer

Authors: H. Yan, R. Sun, X. Pan, Z. Li, X. Guo and L. Gao

Previous study has shown that miR-122, miR-378, and their target gene IL1A may play crucial roles in the tumorigenesis of colorectal cancer (CRC). An insertion/deletion polymorphism(rs3783553 TTCA/-) in the 3' untranslated region of IL1A has been identified as a contributing factor to the risk of developing several cancers. The aim of this study was to ev.. Read More»

Genet. Mol. Res. 14(3):

2015.July.28.17

DOI:

10.4238/2015.July.28.17

Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy

Authors: X.-L. Xu, Y.-L. Yao, W.-Z. Xu, J.-G. Feng and W.-M. Mao

Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with respo.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.15.16

DOI:

http://dx.doi.org/10.4238/2015.April.15.16