Cancer
Genetic variation in ERCC1 and XPF genes and breast cancer risk
Authors: X.H. Pei, Z. Yang, X.Q. Lv, and H.X. Li,
Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were g.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.6
- DOI:
- 10.4238/2014.March.31.6
Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis
Authors: X.L. Wang, J.T. Jiang and C.P. Wu
Tumor-associated macrophages (TAMs), which play a crucial role in the tumor microenvironment, can be divided into M1 and M2 phenotypes, these phenotypes may exert opposite effects on the prognoses of patients with gastric cancer (GC). The association between TAMs and GC is contentious. Thus, a meta-analysis of 12 studies (inco.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049040
- DOI:
- 10.4238/gmr15049040
Acidic and basic fibroblast growth factor expression levels in cervical cancer and their effects on tumor cell proliferation
Authors: Q.H. Zhang, P. Xu, Y.X. Lu and H.T. Dou
Fibroblast growth factors (FGFs) play important roles in angiogenesis, wound healing, embryonic development, and endocrine signaling pathways. Increasingly, recent studies have reported aberrant FGF expression in various malignancies. However, the involvement of FGFs in cervical carcinoma pathogenesis remains unclear. We aimed.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049043
- DOI:
- 10.4238/gmr15049043
Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population
Authors: W.Y. Gan, H.M. Li, Y.G. Zhang, C.M. Li and Y. Wang
Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048822
- DOI:
- 10.4238/gmr15048822
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Authors: Y.Q. Jiang, X.P. Xu, Q.M. Guo, X.C. Xu, Q.Y. Liu, S.H. An, J.L. Xu, F. Su and J.B. Tai
Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer c.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038336
- DOI:
- 10.4238/gmr.15038336
Meta-analysis demonstrates association of XRCC1 genetic polymorphism Arg399Gln with esophageal cancer risk in the Chinese population
Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu
We made a meta-analysis of the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and esophageal cancer (EC) risk. Statistical analysis was performed with the Review Manager version 4.2.8 software program and STATA version 11.0. We selected 16 case-control studies for this meta-analysis, including 3591 EC cases and.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.16.2
- DOI:
- 10.4238/2013.January.16.2
Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese
Authors: Z.M. Zhao, C.G. Li, M.G. Hu, G.D. Zhao and R. Liu
This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DN.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.10
- DOI:
- 10.4238/2014.September.5.10
Lack of association between the interleukin 6 gene -174G>C polymorphism and colorectal cancer: evidence from a meta-analysis
Authors: J.J. Hu, Z.T. Wang and J. Zhong
Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studie.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.2
- DOI:
- 10.4238/2013.July.8.2
Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer
Authors: D.S. Vasconcelos, F.P.E. da Silva, L.G. Quintana, N.P. Anselmo, M.A.K. Othman, T. Liehr and E.H.C. de Oliveira
Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor ge.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.15
- DOI:
- 10.4238/2013.January.4.15
Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis
Authors: Y.L. Wang, W.G. Gong and Q.L. Yuan
Thyroid cancer is the most common type of endocrine tumor. MicroRNAs (miRNAs) play a critical role in a variety of diseases, especially cancer occurrence and progression. However, the specific mechanism by which miRNAs trigger disease states has not been fully elucidated. This study aims to investigate the role of miR-27a in t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049070
- DOI:
- 10.4238/gmr15049070