Cancer
Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Gastric cancer is the fourth commonly diagnosed cancer and the second most frequent cause of cancer death worldwide. Genetic variations in ADH1B and ALDH2 may alter the function and activity of the corresponding enzymes, leading to differences in acetaldehyde exposure between drinkers. Cytochrome P4502E1 (CYP4502E1) is a phase.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048904
- DOI:
- 10.4238/gmr15048904
Investigation on the association between IL-10 C819T gene polymorphisms and susceptibility to gastric cancer
Authors: L. Li, X.Y. Tang, L.M. Ye, Q. Yang and Y. Li
We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People’s Hospital betwee.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047915
- DOI:
- 10.4238/gmr15047915
Analysis of fusion gene expression in prostate tumors by using single-end reads
Authors: D.D. Xie, J.Y. Li, Y. Wang, L. Chen and D.X. Yu
Fusion gene expression, a kind of chromosome rearrangement mode, has been strongly linked to prostate cancer diagnosis and prognosis as well as to the Gleason score and the American Joint Committee on Cancer stage assessment. In combination with traditional methods for locating fusion genes and scoring their association with cancer cell growth, proliferat.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.4
- DOI:
- 10.4238/2013.August.12.4
Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population
Authors: Y. Cao, J. Hu, Y. Fang, Q. Chen and H. Li
Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cance.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.8
- DOI:
- 10.4238/2014.September.12.8
Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer
Authors: X. Tan, Y.Y. Wang, X.Y. Chen, L. Xian, J.J. Guo1, G.B. Liang and M.W. Chen
The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-a.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.10
- DOI:
- 10.4238/2014.September.12.10
Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer
Authors: Z.H. Chen, L. Wang and L.P. Luo
We investigated the correlation between the response to chemotherapy in patients and excision repair cross-complimentary group 1 gene (ERCC1) and xeroderma pigmentosum complementation group F gene (XPF) polymorphisms and the effect of these polymorphisms on the clinical outcome of gastric cancer. Samples from a total of 255 patients with.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.15
- DOI:
- 10.4238/2014.September.12.15
Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population
Authors: P. Qi, L. Wang, B. Zhou, W.J. Yao, S. Xu, Y. Zhou and Z.B. Xie
Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide poly.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.2
- DOI:
- 10.4238/2015.June.11.2
Association of MLL3 expression with prognosis in gastric cancer
Authors: B. Li, H.Y. Liu, S.H. Guo, P. Sun, F.M. Gong and B.Q. Jia
Low expression of myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is reportedly associated with gastric cancer and tumor progression. The purpose of this study was to examine the expression of MLL3 in tissue samples of patients with gastric cancer and to analyze the relationship between MLL3 protein expression and clinical.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.18
- DOI:
- 10.4238/2014.September.12.18
Effects of monomethoxypolyethylene glycol-chitosan nanoparticle-mediated dual silencing of livin and survivin genes in prostate cancer PC-3M cells
Authors: A.Q. Yang, P.J. Wang, T. Huang, W.L. Zhou and J. Landman
Monomethoxypolyethylene glycol-chitosan (mPEG-CS) nanoparticles were used as interfering RNA carriers to transfect human prostate cancer PC-3M cells to evaluate the effects of livin and survivin gene silencing on the proliferation and apoptosis. mPEG-CS nanoparticles with sizes of approximately 60 nm were first synthesized by .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027430
- DOI:
- 10.4238/gmr.15027430
Comparative proteomic analysis of ductal and lobular invasive breast carcinoma
Authors: N.C.S. Oliveira, T.H.B. Gomig, H.H. Milioli, F. Cordeiro, G.G. Costa, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027701
- DOI:
- 10.4238/gmr.15027701