Cancer
Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression
Authors: Z. Peng and Y. Zhang
Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027078
- DOI:
- 10.4238/gmr.15027078
Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis
Authors: N. Wang, P. Chen, L.P. Huang and T.Z. Wang
Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027350
- DOI:
- 10.4238/gmr.15027350
MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation
Authors: Y. Yang, L.J. Yang, M.Z. Deng, Y.Y. Luo, S. Wu, L. Xiong, D. Wang,Y. Liu and H. Liu
Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochra.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027615
- DOI:
- 10.4238/gmr.15027615
Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer
Authors: L. Liu, T. Meng, Q.S. Wang, H.Z. Jin, Z.Q. Sun, B. Jin, F. Fang and H.J. Wang
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance o.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027704
- DOI:
- 10.4238/gmr.15027704
Prediction efficiency of PITX2 DNA methylation for prostate cancer survival
Authors: Z.M. Luan, H. Zhang and X.L. Qu
This study determined the level of PITX2 methylation in prostate cancer and benign tissues and its relationship with the postoperative survival rate. Forty-four patients with prostate cancer who underwent radical prostatectomy and 43 patients with benign prostatic hyperplasia were selected. DNA was extracted from the tissues a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026750
- DOI:
- 10.4238/gmr.15026750
Association between RASSF1A promoter methylation and renal cell cancer susceptibility: a meta-analysis
Authors: Y.Q. Huang, H. Guan, C.H. Liu,D.C. Liu, B. Xu, L. Jiang, Z.X. Lin and M. Chen
Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published st.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026994
- DOI:
- 10.4238/gmr.15026994
Mammaglobin and maspin transcripts in blood may reflect disease progression and the effect of therapy in breast cancer
Authors: O. Bitisik, P. Saip, S. Saglam, D. Derin and N. Dalay
Detection of residual tumor cells in the circulation can provide prognostic as well as therapeutic information and help in identifying patients at high risk for developing metastases. Maspin and mammaglobin are two molecules that are specifically associated with breast cancer. We looked for mammaglobin and maspin transcripts i.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr649
- DOI:
- 10.4238/vol9-1gmr649
Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients
Authors: H.X. Peng, X. Xu, R. Yang, Y.M. Chu, D.M. Yang, Y. Xu, F.L. Zhou, W.Z. Ma, X.J. Zhang, M. Guan, Z.H. Yang and Z.D. Jin
Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese pati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027689
- DOI:
- 10.4238/gmr.15027689
MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation
Authors: W. Peng, Z.-Y. Chen, L. Wang, Z. Wang and J. Li
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of targeted mRNAs. An increasing amount of evidence indicates that miRNAs play important role in cancer pathogenesis, apoptosis, proliferation, and differentiation as oncogenes or tumor suppressors. Recently, miRNA-199a has been shown to be involved in many human cancers, although .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.5
- DOI:
- 10.4238/2013.August.20.5
Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer
Authors: X. Chen, X.S. Liu, H.Y. Liu, Y.Y. Lu and Y. Li
Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027702
- DOI:
- 10.4238/gmr.15027702