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Cancer

Human Genetics   Research Article

Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients

Authors: M. Taheri, F. Mahjoubi and R. Omranipour

One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports ma.. Read More»

Genet. Mol. Res. 9(1):
vol9-1gmr669
DOI:
10.4238/vol9-1gmr669
Human Genetics   Research Article

Effect of cyclosporin A particles of varying diameters on gastric cancer cell apoptosis

Authors: X.L. Xing, Y. Lu and H.L. Qiu

Human health is significantly threatened by gastric cancer, which is the most common malignant tumor; although drastic, surgery is currently the only way to cure it. However, high recurrence rates and low survival rates are associated with the disease. Therefore, to improve the effectiveness of gastric cancer treatment and to .. Read More»

Genet. Mol. Res. 15(2):
gmr.15028085
DOI:
10.4238/gmr.15028085
Human Genetics   Research Article

CYP1A2-163C/A (rs762551) polymorphism and bladder cancer risk: a case-control study

Authors: Y.L. Song, L. Wang, J.C. Ren and Z.H. Xu

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differen.. Read More»

Genet. Mol. Res. 15(2):
gmr.15026298
DOI:
10.4238/gmr.15026298
Bioinformatics   Research Article

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu

The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. .. Read More»

Genet. Mol. Res. 12(3):
2013.January.4.22
DOI:
10.4238/2013.January.4.22
Human Genetics   Research Article

Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer

Authors: D.L. Zheng, G.D. Tang, Y.N. Chen, T. Zhang and M.B. Qin

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platin.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027384
DOI:
10.4238/gmr.15027384
Human Genetics   Research Article

TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis

Authors: X.P. Lu, G.N. Hu, J.Q. Du and H.Q. Li

Numerous studies have evaluated the association between TCF7L2 gene polymorphisms (rs12255372 and rs7903146) and breast cancer risk. However, the results have been inconsistent. Therefore, in the current study, we performed a meta-analysis. A systematically literature search of the PubMed and EMBASE databases was conducted in November 2013, and the refere.. Read More»

Genet. Mol. Res. 14(1):
2015.March.31.16
DOI:
10.4238/2015.March.31.16
Cytogenomics   Research Article

CASP-9 gene functional polymorphisms and cancer risk: a large-scale association study plus meta-analysis

Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu

We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981*T allele and the rs4645981*T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% c.. Read More»

Genet. Mol. Res. 12(3):
2013.February.28.22
DOI:
10.4238/2013.February.28.22
Medical Genetics   Research Article

Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

Authors: S. Chen, X.C. Zhu, Y.L. Liu, C. Wang and K.G. Zhang

We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies .. Read More»

Genet. Mol. Res. 15(3):
gmr.15038342
DOI:
10.4238/gmr.15038342
Human Genetics   Research Article

Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer

Authors: J.H. Sun, N. Fan and Y. Zhang

In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was.. Read More»

Genet. Mol. Res. 15(3):
gmr.15038632
DOI:
10.4238/gmr.15038632
Human Genetics   Research Article

Association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk in a Chinese population

Authors: X.F. Li, X.Q. Jiang, J.W. Zhang and Y.J. Jia

The association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk has not been investigated. In this hospital-based case-control study, we analyzed 256 patients with cervical cancer and 250 healthy controls. Pearson chi-square test was used to examine differences in the distribution of genotype.. Read More»

Genet. Mol. Res. 15(1):
gmr.15016357
DOI:
10.4238/gmr.15016357